The work was done at the Veterinary Teaching Hospitals at Michigan State University and at the Hebrew University of Jerusalem
Alterations in Adipokines in Feline Hepatic Lipidosis
Article first published online: 10 MAR 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 2, pages 242–249, March/April 2013
How to Cite
Mazaki-Tovi, M., Abood, S.K., Segev, G. and Schenck, P.A. (2013), Alterations in Adipokines in Feline Hepatic Lipidosis. Journal of Veterinary Internal Medicine, 27: 242–249. doi: 10.1111/jvim.12055
- Issue published online: 15 MAR 2013
- Article first published online: 10 MAR 2013
- Manuscript Accepted: 21 JAN 2013
- Manuscript Revised: 18 DEC 2012
- Manuscript Received: 20 MAY 2012
- American Academy of Veterinary Nutrition–Waltham USA
Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid-lowering and insulin-sensitizing effects.
Serum concentrations of adiponectin and leptin are altered in feline HL.
Client-owned cats: 55 healthy and 45 with liver disease.
Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined.
Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 μg/mL), HL and concurrent disease (4.4 μg/mL), or other liver disease (6.1 μg/mL), as compared with healthy cats (1.5 μg/mL; P < .001, P < .001, and P = .04, respectively). Mean serum concentration of leptin was higher in cats with HL (9.8 ng/mL) or HL and concurrent disease (10.7 ng/mL) than healthy cats (4.9 ng/mL, P < .001 and P < .001, respectively). Cats with other liver disease had leptin concentration (4.9 ng/mL) similar to healthy cats. Concentrations of adiponectin were correlated with alanine aminotransferase activity (r = 0.40, P = .0069), and concentrations of leptin were correlated with alkaline phosphatase activity (r = 0.42, P = .0051) in cats with liver disease.
Conclusions and Clinical Importance
Adipokine concentrations are altered in feline HL. Increased concentrations of adiponectin are related to liver disease, whereas increased concentrations of leptin are specifically related to HL.