Presented in abstract form at the 2007 ACVIM Forum, Seattle, WA. Published in abstract form in the 2007 ACVIM Forum Proceedings
Adiposity, Plasma Insulin, Leptin, Lipids, and Oxidative Stress in Mature Light Breed Horses
Version of Record online: 20 MAR 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 3, pages 576–582, May/June 2013
How to Cite
Pleasant, R.S., Suagee, J.K., Thatcher, C.D., Elvinger, F. and Geor, R.J. (2013), Adiposity, Plasma Insulin, Leptin, Lipids, and Oxidative Stress in Mature Light Breed Horses. Journal of Veterinary Internal Medicine, 27: 576–582. doi: 10.1111/jvim.12056
- Issue online: 9 MAY 2013
- Version of Record online: 20 MAR 2013
- Manuscript Accepted: 21 JAN 2013
- Manuscript Revised: 1 JAN 2013
- Manuscript Received: 28 MAR 2012
- Virginia Horse Industry Board, Virginia Tech
- Macromolecular Interfaces with Life Sciences (MILES) Integrative Graduate Education
- Research Traineeship (IGERT) of the National Science Foundation. Grant Number: DGE-0333378
- Body condition;
- Equine metabolic syndrome;
- Plasma insulin
Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids.
To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses.
300 randomly selected light breed horses, aged 4–20 years.
A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 – August 15, 2006, with all sampling performed between 0600 and 1200 hours. Concentrate feed was withheld for at least 10 hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators.
Overconditioned and obese horses had higher plasma insulin (P < .001) and leptin (P < .01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P = .006) and lower red blood cell gluthathione peroxidase activities (P = .001) than optimally conditioned horses.
Conclusions and Clinical Importance
Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.