Metabolic and Endocrine Profiles in Sick Neonatal Foals Are Related to Survival
Version of Record online: 25 MAR 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 3, pages 567–575, May/June 2013
How to Cite
Armengou, L., Jose-Cunilleras, E., Ríos, J., Cesarini, C., Viu, J. and Monreal, L. (2013), Metabolic and Endocrine Profiles in Sick Neonatal Foals Are Related to Survival. Journal of Veterinary Internal Medicine, 27: 567–575. doi: 10.1111/jvim.12064
This study was partially presented as oral communication at the 5th European College of Equine Internal Medicine Congress in Edinburgh (UK), February 2012
- Issue online: 9 MAY 2013
- Version of Record online: 25 MAR 2013
- Manuscript Accepted: 30 JAN 2013
- Manuscript Revised: 18 JAN 2013
- Manuscript Received: 22 FEB 2012
- CIRCI ;
- neonatal septicemia;
Sick neonatal foals suffer from a variety of endocrine and metabolic derangements that may be related to outcome. There are several hepatic and lipid metabolism blood markers that have never been assessed in neonatal foals.
Assess panel of endocrine and metabolic variables in group of sick and healthy neonatal foals in order to describe their relationship with diagnosis and survival.
All neonatal foals referred to Unitat Equina-Fundació Hospital Clínic Veterinari during 3 consecutive foaling seasons and a group of healthy foals.
Observational prospective study. Blood samples were obtained on admission and, when possible, after 24–48 h of hospitalization and immediately before discharge or death. Measured variables were triglycerides, nonsterified fatty acids, glucose, creatinine, urea, γ-glutamyltransferase, glutamate dehydrogenase (GLDH), insulin, cortisol, bile acids, and adrenocorticotropic hormone (ACTH). ACTH/cortisol and glucose/insulin ratios were calculated.
Urea, creatinine, and cortisol had median concentrations in septic and nonseptic foals 2- to 8-fold higher than in the control group (P < .001). Median ACTH concentration in the septic group was approximately 4 times higher than in nonseptic and control foals (P < .001). ACTH/cortisol ratio was significantly lower in sick foals compared to control foals (P < .001). A score was designed including creatinine, GLDH, and cortisol. When ≥2 of these variables were altered (P < .001), the foal had 32 times more risk of dying (OR, 31.7; 95% CI, 7.7–130.3).
Conclusions and Clinical Importance
Plasma creatinine, GLDH, and cortisol should be determined in sick newborn foals on admission because of their association with survival.