The animal phase of the study was performed at Oniris, France. Aldosterone, renin, parathyroid hormone, and urinary albumin were assayed at the Royal Veterinary College, London, UK. All other parts of the study were performed at the National Veterinary School of Toulouse, France.
Effects of Dietary Salt Intake on Renal Function: A 2-Year Study in Healthy Aged Cats
Version of Record online: 3 APR 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 3, pages 507–515, May/June 2013
How to Cite
Reynolds, B.S., Chetboul, V., Nguyen, P., Testault, I., Concordet, D.V., Carlos Sampedrano, C., Elliott, J., Trehiou-Sechi, E., Abadie, J., Biourge, V. and Lefebvre, H.P. (2013), Effects of Dietary Salt Intake on Renal Function: A 2-Year Study in Healthy Aged Cats. Journal of Veterinary Internal Medicine, 27: 507–515. doi: 10.1111/jvim.12074
Results were presented in part at the 2010 American College of Veterinary Internal Medicine Forum, Anaheim, CA and at the 20th European College of Veterinary Internal Medicine—Companion Animal Congress, Toulouse, France, September 9–11, 2010
- Issue online: 9 MAY 2013
- Version of Record online: 3 APR 2013
- Manuscript Accepted: 7 FEB 2013
- Manuscript Revised: 16 JAN 2013
- Manuscript Received: 15 JUN 2012
- Royal Canin SAS, Centre de Recherches
- Blood pressure;
- Glomerular filtration rate;
Increasing salt intake to promote diuresis has been suggested in the management of feline lower urinary tract disease. However, high dietary salt intake might adversely affect blood pressure and renal function.
The objective of this study was to assess the long-term effects of increased salt intake on renal function in healthy aged cats.
This study was controlled, randomized, and blinded. Twenty healthy neutered cats (10.1 ± 2.4 years) were randomly allocated into 2 matched groups. One group was fed a high salt diet (3.1 g/Mcal sodium, 5.5 g/Mcal chloride) and the other a control diet of same composition except for salt content (1.0 g/Mcal sodium, 2.2 g/Mcal chloride). Clinical examination, glomerular filtration rate, blood pressure measurement, cardiac and kidney ultrasonography, and urinary and blood tests were performed before and over 24 months after diet implementation. Statistics were performed using a general linear model.
Sixteen cats completed the 2 year study. The only variables affected by dietary salt intake were plasma aldosterone and urinary sodium/creatinine ratio, respectively, higher and lower in the control group all over the study period and urinary specific gravity, lower in the high salt diet group at 3 months.
Conclusions and Clinical Importance
Glomerular filtration rate (GFR), blood pressure, and other routine clinical pathological variables in healthy aged cats were not affected by dietary salt content. The results of this 2 year study do not support the suggestion that chronic increases in dietary salt intake are harmful to renal function in older cats.