• Open Access

Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity

Authors

  • J. Benito,

    1. Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • B. Hansen,

    1. Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • V. DePuy,

    1. Bowden Statistical Consulting, Oxford, NC
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  • G.S. Davidson,

    1. Clinical Pharmacy Services, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • A. Thomson,

    1. Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • W. Simpson,

    1. Morrisville Cat Hospital, Morrisville, NC
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  • S. Roe,

    1. Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • E. Hardie,

    1. Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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  • B.D.X. Lascelles

    Corresponding author
    1. Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
    • Comparative Pain Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
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Corresponding author: Dr. B.D.X. Lascelles, Comparative Pain Research Laboratory, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607; e-mail: Duncan_Lascelles@ncsu.edu

Abstract

Background

Progress in establishing if therapies provide relief to cats with degenerative joint disease (DJD)-associated pain is hampered by a lack of validated owner-administered assessment methods.

Hypothesis

That an appropriately developed subjective owner-completed instrument (Feline Musculoskeletal Pain Index-FMPI) to assess DJD-associated impairment would have responsiveness and criterion validity.

Animals

Twenty-five client-owned cats with DJD-associated pain.

Methods

FMPI responsiveness (ability to detect the effect of an analgesic treatment) and validity (correlation with an objective measure) were explored through a stratified, randomized, double blinded, placebo-controlled, crossover 10-week clinical study. Meloxicam was administered to effect pain relief. A linear mixed model, backward stepwise regression, and Pearson correlations were used to assess responsiveness and criterion validity with the assumption that the NSAID would increase activity.

Results

Positive responses of cats to placebo (= .0001) and meloxicam treatment (= .0004) were detected; however, the instrument did not detect any difference between placebo and meloxicam (linear mixed model), even for the high impairment cases. Percent meloxicam target dose administered, temperament, and total baseline FMPI score were covariates that most affected FMPI scores. Controlling for significant covariates, most positive effects were seen for placebo treatment. Positive treatment effects on activity were detected, but only for the cases designated as most highly impaired.

Conclusions and Clinical Importance

Neither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study. The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria.

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