• 1
    Brisson BA. Intervertebral disc disease in dogs. Vet Clin North Am Small Anim Pract 2010;40:829858.
  • 2
    Bray JP, Burbidge HM. The canine intervertebral disk: Part one: Structure and function. J Am Anim Hosp Assoc 1998;34:5563.
  • 3
    Priester WA. Canine intervertebral disc disease—Occurrence by age, breed, and sex among 8,117 cases. Theriogenology 1976;6:293303.
  • 4
    Gage ED. Incidence of clinical disc disease in the dog. J Am Anim Hosp Assoc 1975;135:135138.
  • 5
    Ikeda T, Nakamura T, Kikuchi T, et al. Pathomechanism of spontaneous regression of the herniated lumbar disc: Histologic and immunohistochemical study. J Spinal Disord 1996;9:136140.
  • 6
    Doita M, Kanatani T, Ozaki T, et al. Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption. Spine 2001;26:15221527.
  • 7
    Royal AB, Chigerwe M, Coates JR, et al. Cytologic and histopathologic evaluation of extruded canine degenerated disks. Vet Surg 2009;38:798802.
  • 8
    Shimizu J, Mochida K, Kobayashi Y, et al. Inflammatory reaction in the herniated degenerative disc material in miniature dachshunds. J Vet Med Sci 2010;72:8184.
  • 9
    Mateo I, Lorenzo V, Foradada L, Muñoz A. Clinical, pathologic, and magnetic resonance imaging characteristics of canine disc extrusion accompanied by epidural hemorrhage or inflammation. Vet Radiol Ultrasound 2011;52:1724.
  • 10
    Sharp N, Wheeler S. Small Animal Spinal Disorders, 2nd ed. Oxford, England: Elsevier; 2005: p. 44.
  • 11
    Bray JP, Burbidge HM. The canine intervertebral disk. Part two: Degenerative changes—Non-chondrodystrophoid versus chondrodystrophoid disks. J Am Anim Hosp Assoc 1998;34:135144.
  • 12
    Braund KG, Ghosh P, Taylor TK, et al. Morphological studies of the canine intervertebral disc. The assignment of the Beagle to the achondroplastic classification. Res Vet Sci 1975;19:167172.
  • 13
    Hansen HJ. A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand 1951;20:280293.
  • 14
    Hansen HJ. A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis. Acta Orthop Scand Suppl 1952;11:1117.
  • 15
    Bergknut N. Intervertebral disc degeneration in dogs. The Netherlands: Utrecht University; 2010. PhD thesis.
  • 16
    Smolders LA, Bergknut N, Grinwis GC, et al. Intervertebral disc disease in dogs—Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Vet J 2012;195: 156163 PMID 23154070.
  • 17
    Johnson JA, da Costa RC, Allen MJ. Micromorphometry and cellular characteristics of the canine cervical intervertebral discs. J Vet Intern Med 2010;24:13431349.
  • 18
    Kuma V, Abbas AK, Aster J. Inflammation and Repair ed. Robbins Basic Pathology, 8th ed. Philadelphia, PA: Elsevier; 2013: 2975.
  • 19
    Levine JM, Levine GJ, Porter BF. Naturally occurring disk herniation in dogs: An opportunity for pre-clinical spinal cord injury research. J Neurotrauma 2011;28:675688.
  • 20
    Penning V, Platt SR, Dennis R. Association of spinal cord compression seen on magnetic resonance imaging with clinical outcome in 67 dogs with thoracolumbar intervertebral disc extrusion. J Small Anim Pract 2006;47:644650.
  • 21
    Cappello R, Bird JL, Pfeiffer D, et al. Notochordal cell produce and assemble extracellular matrix in a distinct manner, which may be responsible for the maintenance of healthy nucleus pulposus. Spine 2006;31:873882.
  • 22
    Kranenburg HJ, Grinwis GC, Bergknut N, et al. Intervertebral disc disease in dogs—Part 1: Comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. Vet J 2012;195:164171 PMID 22795604.
  • 23
    Bergknut N, Auriemma E, Wijsman S, et al. Evaluation of intervertebral disk degeneration in chondrodystrophic and nonchondrodystrophic dogs by use of Pfirrmann grading of images obtained with low field magnetic resonance imaging. Am J Vet Res 2011;72:893898.
  • 24
    Stigen O, Kolbjornsen O. Calcification of intervertebral discs in the Dachshund: A radiographic and histopathologic study of 20 dogs. Acta Vet Scand 2007;49:39.
  • 25
    Kikuchi T, Nakamura T, Ikeda T, et al. Monocyte chemoattractant protein-1 in the intervertebral disc. A histologic experimental model. Spine 1998;23:10911099.
  • 26
    Murai K, Sakai D, Nakamura Y, et al. Primary immune system responders to nucleus pulposus cells: Evidence for immune response in disc herniation. Eur Cell Mater 2010;19:1321.
  • 27
    Takahashi N, Yabuki S, Aoki Y, et al. Pathomechanisms of nerve root injury caused by disc herniation: An experimental study of mechanical compression and chemical irritation. Spine 2003;28:435441.
  • 28
    Kanerva A, Kommonen B, Grönblad M, et al. Inflammatory cells in experimental intervertebral disc injury. Spine 1997;22:27112715.
  • 29
    Habtemariam A, Virri J, Grönblad M, et al. Inflammatory cells in full-thickness annulus injury in pigs. An experimental disc herniation animal model. Spine 1998;23:524529.
  • 30
    Geiss A, Larsson K, Rydevik B, et al. Autoimmune properties of nucleus pulposus: An experimental study in pigs. Spine 2007;32:168173.
  • 31
    Arai Y, Yasuma T, Shitoto K, et al. Immunohistological study of intervertebral disc herniation of lumbar spine. J Orthop Sci 2000;5:229231.
  • 32
    Hasegawa T, An HS, Inufusa A, et al. The effect of age on inflammatory responses and nerve root injuries after lumbar disc herniation: An experimental study in a canine model. Spine 2000;25:937940.
  • 33
    Haro H, Shinomiya K, Komori H, et al. Upregulated expression of chemokines in herniated nucleus pulposus resorption. Spine 1996;21:16471652.
  • 34
    Habtemariam A, Grönblad M, Virri J, et al. A comparative immunohistochemical study of inflammatory cells in acute-stage and chronic-stage disc herniations. Spine 1998;23:21592165.
  • 35
    Kawaguchi S, Yamashita T, Yokogushi K, et al. Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral discs. Spine 2001;26:12091214.
  • 36
    Kawaguchi S, Yamashita T, Katahira G, et al. Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages. Spine 2002;27:15111516.
  • 37
    Koike Y, Uzuki M, Kokubun S, et al. Angiogenesis and inflammatory cell infiltration in lumbar disc herniation. Spine 2003;28:19281933.
  • 38
    Davalos D, Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol 2012;34:4362.
  • 39
    De Almeida VV, Calado A, Rosário HS, et al. Differential effect of soluble fibrinogen as a neutrophil activator. Microvasc Res 2012;83:332336.
  • 40
    Whelan LC, Morgan MP, McCarthy GM. Basic calcium phosphate crystals as a unique therapeutic target in osteoarthritis. Front Biosci 2005;10:530541.
  • 41
    Cunningham CC, Mills E, Mielke LA, et al. Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase. Clin Immunol 2012;144:228236.
  • 42
    Brisson BA, Moffatt SL, Swayne SL, et al. Recurrence of thoracolumbar intervertebral disk extrusion in chondrodystrophic dogs after surgical decompression with or without prophylactic fenestration: 265 cases (1995–1999). J Am Vet Med Assoc 2004;224:18081814.
  • 43
    Forterre F, Gorgas D, Dickomeit M, et al. Incidence of spinal compressive lesions in chondrodystrophic dogs with abnormal recovery after hemilaminectomy for treatment of thoracolumbar disc disease: A prospective magnetic resonance imaging study. Vet Surg 2010;39:165172.
  • 44
    Roach WJ, Thomas M, Weh JM, et al. Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. Vet Comp Orthop Traumatol 2012;25:109115.
  • 45
    Delauche-Cavallier MC, Budet C, Laredo JD, et al. Lumbar disc herniation. Computed tomography scan changes after conservative treatment of nerve root compression. Spine (Phila Pa 1976) 1992;17:927933.
  • 46
    Mochida K, Komori H, Okawa A, et al. Regression of cervical disc herniation observed on magnetic resonance images. Spine 1998;23:990997.
  • 47
    Vinas FC, Wilner H, Rengachary S. The spontaneous resorption of herniated cervical discs. J Clin Neurosci 2001;8:542546.
  • 48
    Orief T, Orz Y, Attia W, et al. Spontaneous resorption of sequestrated intervertebral disc herniation. World Neurosurg 2012;77:146152.
  • 49
    Kobayashi S, Meir A, Kokubo Y, et al. Ultrastructural analysis on lumbar disc herniation using surgical specimens: Role of neovascularization and macrophages in hernias. Spine 2009;34:655662.
  • 50
    Yoshida M, Nakamura T, Sei A, et al. Intervertebral disc cells produce tumor necrosis factor α, interleukin-1β, and monocyte chemoattractant protein-1 immediately after herniation: An experimental study using a new hernia model. Spine 2005;30:5561.
  • 51
    Goupille P, Jayson MI, Valat JP, et al. The role of inflammation in disk herniation-associated radiculopathy. Semin Arthritis Rheum 1998;28:6071.
  • 52
    Mulleman D, Mammou S, Griffoul I, et al. Pathophysiology of disk-related sciatica. I.- Evidence supporting a chemical component. Joint Bone Spine 2006;73:151158.
  • 53
    Forsythe WB, Ghoshal NG. Innervation of the canine thoracolumbar vertebral column. Anat Rec 1984;208:5763.
  • 54
    Webb AA. Potential sources of neck and back pain in clinical conditions of dogs and cats: A review. Vet J 2003;165:193213.
  • 55
    Hirabayashi S, Kumano K, Tsuiki T, et al. A dorsally displaced free fragment of lumbar disc herniation and its interesting histologic findings. Spine 1990;15:12311233.
  • 56
    Suran JN, Durham A, Mai W, et al. Contrast enhancement of extradural compressive material on magnetic resonance imaging. Vet Radiol Ultrasound 2011;52:610.