The study was done at the veterinary teaching hospital of the University of Montreal
Neonatal Morbidity and Mortality of 31 Calves Derived from Somatic Cloning
Version of Record online: 19 JUN 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 5, pages 1218–1227, September/October 2013
How to Cite
Brisville, A.-C., Fecteau, G., Boysen, S., Desrochers, A., Dorval, P., Buczinski, S., Lefebvre, R., Hélie, P., Blondin, P. and Smith, L.C. (2013), Neonatal Morbidity and Mortality of 31 Calves Derived from Somatic Cloning. Journal of Veterinary Internal Medicine, 27: 1218–1227. doi: 10.1111/jvim.12129
- Issue online: 13 SEP 2013
- Version of Record online: 19 JUN 2013
- Manuscript Accepted: 14 MAY 2013
- Manuscript Revised: 22 FEB 2013
- Manuscript Received: 17 JUL 2012
- Strategic Grant of the NSERC (Natural Sciences and Engineering Research Council)
- Physical congenital defect;
- Umbilical infection
The neonatal period is associated with high morbidity and mortality in cloned calves.
To describe morbidity and mortality in cloned calves from birth to 2 years of age.
Thirty-one somatic cell-derived Holstein calves delivered at a veterinary teaching hospital.
Medical files were retrospectively analyzed.
Four calves were stillborn. Five calves born alive had physical congenital defects. Twenty-three calves had an enlarged umbilical cord. Laboratory abnormalities included acidemia, respiratory acidosis, hyperlactatemia, anemia, stress leukogram, decreased total protein, albumin and globulins, and increased creatinine. Twenty-five calves survived the 1st hour of life. Among them, 11 stood without assistance within 6 hours of birth, 10 calves took longer than 6 hours to stand, and 4 never stood. Twenty-two calves suffered from anorexia. Twelve calves had complications arising from umbilical cord infections. Three calves developed idiopathic hyperthermia (>40°C). Eight calves suffered from gastrointestinal problems, including ruminal distension, abomasal ulcers, neonatal enteritis, intussusception, and abomasal displacement. Mortality between birth and 3 weeks of age was 32% (10/31). Causes of death and reasons for euthanasia included stillbirths, respiratory failure, and limb deformities. Mortality between 3 weeks and 2 years of age was 19% (4/21), with deaths in this group attributed to generalized peritonitis and complications arising from umbilical infections. Overall, mortality rate within 2 years of age was 14/31 (45%).
Conclusion and Clinical Importance
Respiratory problems, limb deformities, and umbilical infections were the most common causes of morbidity and mortality in these cloned calves.