• 1
    Slingerland LI, Fazilova VV, Plantinga EA, et al. Indoor confinement and physical inactivity rather than the proportion of dry food are risk factors in the development of feline type 2 diabetes mellitus. Vet J 2009;179:247253.
  • 2
    Laflamme DP, Abood SK, Fascetti AJ, et al. Pet feeding practices of dog and cat owners in the United States and Australia. J Am Vet Med Assoc 2008;232:687694.
  • 3
    Cave NJ, Allan FJ, Schokkenbroek SL, et al. A cross-sectional study to compare changes in the prevalence and risk factors for feline obesity between 1993 and 2007 in New Zealand. Prev Vet Med 2012;107:121133.
  • 4
    Scarlett JM, Donoghue S, Saidla J, Wills J. Overweight cats: Prevalence and risk factors. Int J Obes Relat Metab Disord 1994;18:2228.
  • 5
    American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011;34(Suppl 1):1161.
  • 6
    Prahl A, Guptill L, Glickman NW, et al. Time trends and risk factors for diabetes mellitus in cats presented to veterinary teaching hospitals. J Feline Med Surg 2007;9:351358.
  • 7
    Frank G, Anderson W, Pazak H, et al. Use of a high-protein diet in the management of feline diabetes mellitus. Vet Ther 2001;2:238246.
  • 8
    Kirk CA. Feline diabetes mellitus: Low carbohydrates versus high fiber? Vet Clin North Am Small Anim Pract 2006;36:12971306.
  • 9
    American Diabetes Association. Postprandial blood glucose. Diabetes Care 2001;24:775778.
  • 10
    Rand JS. Feline diabetes mellitus. In: Mooney CT, Peterson ME, eds. BSAVA Manual of Canine and Feline Endocrinology. West Sussex, UK: British Small Animal Veterinary Association; 2012:133147.
  • 11
    Ceriello A, Colagiuri S. International Diabetes Federation guideline for management of postmeal glucose: A review of recommendations. Diabet Med 2008;25:11511156.
  • 12
    Toschi E, Camastra S, Sironi AM, et al. Effect of acute hyperglycemia on insulin secretion in humans. Diabetes 2002;51:S130S133.
  • 13
    Leahy J, Bonner-Weir S, Weir G. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 1988;81:14071414.
  • 14
    Poitout V. Glucolipotoxicity of the pancreatic beta-cell: Myth or reality? Biochem Soc Trans 2008;36:901904.
  • 15
    Appleton DJ, Rand JS, Priest J, Sunvold GD. Determination of reference values for glucose tolerance, insulin tolerance, and insulin sensitivity tests in clinically normal cats. Am J Vet Res 2001;62:630636.
  • 16
    Coradini M, Rand JS, Morton JM, Rawlings JM. Effects of commercially available feline diets on glucose and insulin concentrations, insulin sensitivity and energetic efficiency of weight gain. Br J Nutr 2011;106(Suppl 1):S64S77.
  • 17
    Farrow H, Rand JS, Morton JM, Sunvold G. Postprandial glycemia in cats fed a moderate carbohydrate meal persists for a median of 12 hours, and female cats have higher peak glucose concentrations. J Feline Med Surg 2012;14:706715.
  • 18
    Appleton DJ, Rand JS, Priest J, et al. Dietary carbohydrate source affects glucose concentrations, insulin secretion, and food intake in overweight cats. Nutr Res 2004;24:447467.
  • 19
    Hewson-Hughes A, Gilham M, Upton S, et al. The effect of dietary starch level on post-prandial glucose and insulin concentration in cats and dogs. Br J Nutr 2011;106:S105S109.
  • 20
    Crenshaw KL, Peterson ME. Pretreatment clinical and laboratory evaluation of cats with diabetes mellitus: 104 cases (1992–1994). J Am Vet Med Assoc 1996;209:943949.
  • 21
    Bennett N, Greco DS, Peterson ME, et al. Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus. J Feline Med Surg 2006;8:7384.
  • 22
    Link KRJ, Rand JS, Hendrikz JK. Evaluation of a simplified intravenous glucose tolerance test and a reflectance glucose meter for use in cats. Vet Rec 1997;140:253256.
  • 23
    Sunvold GD, Bouchard GF. Assessment of obesity and associated metabolic disorders. In: Reinhart GA, Carey DP, eds. Recent Advances in Canine and Feline Nutrition, 1st ed. Wilmington, OH: Orange Frazer Press; 1998:135148.
  • 24
    Farrow HA, Rand JS, Burgess D, et al. Surgically implanted vascular access ports evaluated for frequent, long-term blood sampling in cats. Res Vet Sci 2013; Epublication ahead of print version.
  • 25
    Martin GJ, Rand JS. Food intake and blood glucose in normal and diabetic cats fed ad libitum. J Feline Med Surg 1999;1:241251.
  • 26
    Link KRJ, Rand JS. Reference values for glucose tolerance and glucose tolerance status in cats. J Am Vet Med Assoc 1998;213:492496.
  • 27
    Rowland M, Tozer TN. Assessment of AUC. In: Rowland M, Tozer TN, eds. Clinical Pharmacokinetics: Concepts and Applications, 3rd ed. Media, PA: Williams & Wilkins; 1995:469472.
  • 28
    Marshall RD, Rand JS, Morton JM. Glargine and protamine zinc insulin have a longer duration of action and result in lower mean daily glucose concentrations than lente insulin in healthy cats. J Vet Pharmacol Ther 2008;31:205212.
  • 29
    National Research Council. Nutrient requirements and signs of deficiency. In: Subcommittee on Dog Nutrition, Committee on Animal Nutrition, Board on Agriculture, ed. Nutrient Requirements of Dogs. Washington, DC: The National Academies Press; 1985:238.
  • 30
    National Research Council. Energy. In: Subcommittee on Dog and Cat Nutrition, Committee on Animal Nutrition, ed. Nutrient Requirements of Dogs and Cats. Washington, DC: The National Academies Press; 2006:2848.
  • 31
    Abramson JH. WINPEPI updated: Computer programs for epidemiologists, and their teaching potential. Epidemiol Perspect Innov 2011;8:1.
  • 32
    Appleton DJ, Rand JS, Sunvold GD. Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. J Feline Med Surg 2001;3:211228.
  • 33
    Marshall RD, Rand JS, Morton JM. Treatment of newly diagnosed diabetic cats with glargine insulin improves glycaemic control and results in higher probability of remission than protamine zinc and lente insulins. J Feline Med Surg 2009;11:683691.
  • 34
    Roomp K, Rand J. Evaluation of detemir in diabetic cats managed with a protocol for intensive blood glucose control. J Feline Med Surg 2012;14:566572.
  • 35
    Feldman EC, Nelson RW. Feline diabetes mellitus. In: Feldman EC, Nelson RW, eds. Canine and Feline Endocrinology and Reproduction, 3rd ed. St Louis, MO: Saunders; 2004:539579.
  • 36
    Hewson-Hughes A, Gilham M, Upton M, et al. Post-prandial glucose and insulin profiles following glucose-loaded meal in cats and dogs. Br J Nutr 2011;106:S101S104.
  • 37
    Elliott KF, Rand J, Fleeman L, et al. A diet lower in digestible carbohydrate results in lower postprandial glucose concentrations compared with a traditional canine diabetes diet and an adult maintenance diet in healthy dogs. Res Vet Sci 2012;93:288295.
  • 38
    Ballard FJ. Glucose utilization in mammalian liver. Comp Biochem Physiol 1965;14:437443.
  • 39
    Washizu T, Tanaka A, Sako T, et al. Comparison of the activities of enzymes related to glycolysis and gluconeogenesis in the liver of dogs and cats. Res Vet Sci 1999;67:205206.
  • 40
    Hewson-Hughes AK, Hewson-Hughes VL, Miller AT, et al. Geometric analysis of macronutrient selection in the adult domestic cat, Felis catus. J Exp Biol 2011;214:10391051.
  • 41
    Batchelor DJ, Al-Rammahi M, Moran AW, et al. Sodium/glucose cotransporter-1, sweet receptor, and disaccharidase expression in the intestine of the domestic dog and cat: Two species of different dietary habit. Am J Physiol Regul Integr Comp Physiol 2011;300:6775.
  • 42
    Wei A, Fascetti AJ, Liu KJ, et al. Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food. J Anim Physiol Anim Nutr 2011;95:359367.
  • 43
    Mori A, Sako T, Lee P, et al. Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats. Vet Res Commun 2009;33:669680.
  • 44
    Martin LJM, Siliart B, Lutz TA, et al. Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. Br J Nutr 2010;103:16101619.
  • 45
    Verbrugghe A, Hesta M, Van Weyenberg S, et al. The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: The domestic cat (Felis catus). Br J Nutr 2010;104:214221.
  • 46
    Hoenig M, Jordan ET, Glushka J, et al. Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats. Am J Physiol Regul Integr Comp Physiol 2011;301:R1798R1807.
  • 47
    Rocchini AP, Marker P, Cervenka T. Time course of insulin resistance associated with feeding dogs a high-fat diet. Am J Physiol Endocrinol Metab 1997;272:E147E154.
  • 48
    Ahrén B, Winzell MS, Pacini G. The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice. Endocrinol 2008;197:181187.
  • 49
    Strack TR, Poussier P, Marliss EB, Albisser AM. Glucose-turnover after a mixed meal in dogs: Glucoregulation without change in arterial glycemia. Am J Physiol 1994;266:R889R895.
  • 50
    van Loon LJC, Kruijshoop M, Menheere P, et al. Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. Diabetes Care 2003;26:625630.
  • 51
    Newsholme P, Brennan L, Bender K. Amino acid metabolism, beta-cell function, and diabetes. Diabetes 2006;55:S39S47.
  • 52
    Wolever TM, Bolognesi C. Prediction of glucose and insulin responses of normal subjects after consuming mixed meals varying in energy, protein, fat, carbohydrate and glycemic index. J Nutr 1996;126:28072812.
  • 53
    Nguyen P, Dumon H, Buttin P, et al. Composition of meal influences changes in postprandial incremental glucose and insulin in healthy dogs. J Nutr 1994;124:2707S2711S.
  • 54
    Backus RC, Cave NJ, Keisler DH. Gonadectomy and high dietary fat but not high dietary carbohydrate induce gains in body weight and fat of domestic cats. Br J Nutr 2007;98:641650.
  • 55
    Nguyen PG, Dumon HJ, Siliart BS, et al. Effects of dietary fat and energy on body weight and composition after gonadectomy in cats. Am J Vet Res 2004;65:17081713.
  • 56
    McCann TM, Simpson KE, Shaw DJ, et al. Feline diabetes mellitus in the UK: The prevalence within an insured cat population and a questionnaire-based putative risk factor analysis. J Feline Med Surg 2007;9:289299.
  • 57
    Nelson RW, Scott-Moncrieff JC, Feldman EC, et al. Effect of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus. J Am Vet Med Assoc 2000;216:10821088.