Comparative Effect of Carperitide and Furosemide on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation
Article first published online: 19 AUG 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 5, pages 1097–1104, September/October 2013
How to Cite
Suzuki, S., Fukushima, R., Yamamoto, Y., Ishikawa, T., Hamabe, L., Kim, S., Yoshiyuki, R., Fukayama, T., Machida, N. and Tanaka, R. (2013), Comparative Effect of Carperitide and Furosemide on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation. Journal of Veterinary Internal Medicine, 27: 1097–1104. doi: 10.1111/jvim.12154
- Issue published online: 13 SEP 2013
- Article first published online: 19 AUG 2013
- Manuscript Accepted: 8 JUL 2013
- Manuscript Revised: 24 MAY 2013
- Manuscript Received: 22 SEP 2012
- Mitsubishi Chemical Medience Corporation
- Atrial natriuretic peptide;
- Mitral valve disease
The effects of carperitide on left atrial pressure (LAP) in dogs with mitral valve disease (mitral regurgitation, MR) have not been documented.
The objective was to compare the short-term effects of carperitide versus furosemide on LAP and neurohumoral factors in MR dogs.
Six healthy Beagle dogs weighing 9.8–12.6 kg (2 males and 4 females; aged 3 years) were used.
Experimental, randomized, cross-over, and interventional study. Carperitide 0.1 μg/kg/min or furosemide 0.17 mg/kg/h (1 mg/kg/6 h) was administered to dogs with surgically induced MR for 6 hours, and after a 14 day wash-out period, the other drug was administered. LAP, plasma renin activity, plasma aldosterone, and echocardiographic variables were measured.
Left atrial pressure was decreased similarly after the administration of carperitide 0.1 μg/kg/min and furosemide 0.17 mg/kg/h (1 mg/kg/6 h) compared with baseline in dogs with MR (Baseline 14.75 ± 3.74 mmHg, carperitide 10.24 ± 4.97 mmHg, P < .01, furosemide 10.77 ± 5.06 mmHg, P < .05). Plasma renin activity and plasma aldosterone were significantly lower after the administration of carperitide than after the administration of furosemide (P < .05, respectively).
Conclusions and Clinical Importance
Carperitide significantly decreased LAP in dogs with acute MR caused by experimental chordal rupture. Carperitide can have additional benefits from the viewpoint of minimal activation of neurohumoral factors in the treatment of dogs with MR. Additional studies in dogs with spontaneous disease are warranted.