The results of this study were presented at the 22nd ECVIM-CA Annual Congress, 2012, Maastricht, The Netherlands
Hypovitaminosis D in Dogs with Spirocercosis
Article first published online: 19 AUG 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 5, pages 1159–1164, September/October 2013
How to Cite
Rosa, C.T., Schoeman, J.P., Berry, J.L., Mellanby, R.J. and Dvir, E. (2013), Hypovitaminosis D in Dogs with Spirocercosis. Journal of Veterinary Internal Medicine, 27: 1159–1164. doi: 10.1111/jvim.12161
- Issue published online: 13 SEP 2013
- Article first published online: 19 AUG 2013
- Manuscript Accepted: 16 JUL 2013
- Manuscript Revised: 22 MAY 2013
- Manuscript Received: 31 JAN 2013
- Vitamin D
Spirocercosis in dogs is characterized by esophageal nodules that can undergo neoplastic transformation. Hypovitaminosis D has been associated with neoplasia formation. We hypothesized hypovitaminosis D in neoplastic spirocercosis and that it could be a risk factor for neoplastic transformation.
To measure and compare vitamin D status, assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations in non-neoplastic (n = 25) and neoplastic (n = 26) spirocercosis client-owned dogs and healthy dogs (n = 24).
Twenty-five non-neoplastic dogs, 26 neoplastic dogs, and 24 healthy dogs.
Fifty-one dogs were randomly selected from 119 dogs diagnosed with spirocercosis presenting to our hospital, and further divided into non-neoplastic or neoplastic groups. Exclusion criteria included dogs less than 1 year old, with concurrent diseases, received corticosteroids, or treated prophylactically for spirocercosis. Serum 25(OH)D concentration was measured by high-performance liquid chromatography. Spirocercosis dogs' appetites were graded and compared.
Serum 25(OH)D concentrations were significantly different among all groups (P < .001). 25-Hydroxyvitamin D concentrations were significantly lower in neoplastic group (median 30.7 nmol/L [range 14.7–62.2]) compared to non-neoplastic (median 52.7 nmol/L [range 19.1–129.7, P < .05]) and healthy groups (median 74.6 nmol/L [range 37.4–130.5, P < .005]). 25-hydroxyvitamin D concentrations were significantly lower in non-neoplastic spirocercosis dogs compared to healthy ones (P < .05). Neoplastic and non-neoplastic spirocercosis dogs had similar appetite scores (P = 1.0). 25-Hydroxyvitamin D concentrations were not significantly different between dogs with normal (P = .087) and abnormal (P = .125) appetites within neoplastic and non-neoplastic spirocercosis groups.
Conclusions and Clinical Importance
Further studies are warranted to determine potential use of vitamin D treatment in spirocercosis and explore role of hypovitaminosis D in pathogenesis of malignant transformation.