• Open Access

Prevalence of Immune-Complex Glomerulonephritides in Dogs Biopsied for Suspected Glomerular Disease: 501 Cases (2007–2012)

Authors

  • S.M. Schneider,

    Corresponding author
    1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biological Sciences, Texas A&M University, College Station, TX
    • Corresponding author: S. Schneider, Department of Veterinary Pathobiology, College of Veterinary Medicine, 4467 TAMU, College Station, TX 77843-4467; e-mail: sschneider@cvm.tamu.edu.

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  • R.E. Cianciolo,

    1. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH
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  • M.B. Nabity,

    1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biological Sciences, Texas A&M University, College Station, TX
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  • F.J. Clubb Jr,

    1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biological Sciences, Texas A&M University, College Station, TX
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  • C.A. Brown,

    1. Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA
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  • G.E. Lees

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biological Sciences, Texas A&M University, College Station, TX
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  • Presented in part at the 63rd Annual Meeting of the American College of Veterinary Pathologists and the 47th Annual Meeting of the American Society for Veterinary Clinical Pathologists, Seattle, Washington on Dec 1-5, 2012

Abstract

Background

Glomerulonephropathies are common causes of kidney disease in dogs.

Objective

To determine the prevalence of immune-complex glomerulonephritis (ICGN) in North American dogs biopsied for suspected glomerular disease.

Animals

Renal biopsies (n = 733) submitted to the Texas Veterinary Renal Pathology Service between January 1, 2007 and December 31, 2012 were reviewed. Dogs were included if the biopsy was performed for suspected glomerular disease.

Methods

Specimens were evaluated by light microscopy (LM), immunofluorescence (IF), and transmission electron microscopy (TEM). Findings were retrospectively evaluated to categorize the diagnosis for each case. For the diagnosis of ICGN, TEM findings were considered conclusive when LM and IF were equivocal.

Results

Of the 501 dogs included in the study, 241 (48.1%) had ICGN; 103 (20.6%) had primary glomerulosclerosis; 76 (15.2%) had amyloidosis; 45 (9.0%) had nonimmune complex (IC) glomerulopathy; 24 (4.8%) had non-IC nephropathy; and, 12 (2.4%) had primary tubulointerstitial disease. Many (66/241; 27.4%) ICGN cases required TEM for definitive diagnosis, including 14 cases (5.8%) that were not suspected on LM. Of cases not diagnosed as ICGN, a substantial proportion (60/260; 23.1%) required TEM to rule out immune complex deposits, including 14 of 189 cases (7.4%) presumptively diagnosed as ICGN on LM.

Conclusions and Clinical Importance

Approximately half of all dogs biopsied for suspected glomerular disease had conditions other than ICGN. Renal biopsy is needed to accurately categorize the underlying disease and direct appropriate treatment. Additionally, TEM and IF evaluations by experienced nephropathologists are necessary to obtain an accurate diagnosis in many cases.

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