Serum C-Reactive Protein as a Diagnostic Biomarker in Dogs with Bacterial Respiratory Diseases
Version of Record online: 18 DEC 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 1, pages 84–91, January/February 2014
How to Cite
Viitanen, S.J., Laurila, H.P., Lilja-Maula, L.I., Melamies, M.A., Rantala, M. and Rajamäki, M.M. (2014), Serum C-Reactive Protein as a Diagnostic Biomarker in Dogs with Bacterial Respiratory Diseases. Journal of Veterinary Internal Medicine, 28: 84–91. doi: 10.1111/jvim.12262
- Issue online: 15 JAN 2014
- Version of Record online: 18 DEC 2013
- Manuscript Accepted: 23 OCT 2013
- Manuscript Revised: 25 SEP 2013
- Manuscript Received: 22 JUL 2013
- Acute-phase protein;
C-reactive protein (CRP) is a major acute-phase protein in dogs. Serum concentrations are low in healthy animals, but increase rapidly after inflammatory stimuli.
The aim of the study was to investigate CRP concentrations in various respiratory diseases of dogs and to determine if CRP can be used as a biomarker in the diagnosis of bacterial respiratory diseases.
A total of 106 privately owned dogs with respiratory diseases (17 with bacterial tracheobronchitis [BTB], 20 with chronic bronchitis [CB], 20 with eosinophilic bronchopneumopathy [EBP], 12 with canine idiopathic pulmonary fibrosis [CIPF], 15 with cardiogenic pulmonary edema [CPE], and 22 with bacterial pneumonia [BP]) and 72 healthy controls.
The study was conducted as a prospective cross-sectional observational study. CRP was measured in serum samples. Diagnosis was confirmed by clinical and laboratory findings, diagnostic imaging, and selected diagnostic methods such as cytological and microbiological analysis of respiratory samples, echocardiography, and histopathology.
Dogs with BP had significantly higher CRP concentrations (median, 121 mg/L; interquartile range, 68–178 mg/L) than dogs with BTB (23, 15–38, P = .0003), CB (13, 8–14, P < .0001), EBP (5, 5–15, P < .0001), CIPF (17, 10–20, P < .0001), or CPE (19, 13–32, P < .0001) and healthy controls (14, 8–20, P < .0001). Dogs with BTB had significantly higher CRP concentrations than dogs with CB (P = .001) or EBP (P < .0001) and healthy controls (P = .029).
Conclusion and Clinical Importance
These results indicate that CRP has potential for use as an additional biomarker, especially in the diagnostics of BP.