All clinical work was carried out at Texas A&M University.
Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009)
Article first published online: 26 DEC 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 2, pages 401–410, March/April 2014
How to Cite
Saunders, A.B., Gordon, S.G., Boggess, M.M. and Miller, M.W. (2014), Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009). Journal of Veterinary Internal Medicine, 28: 401–410. doi: 10.1111/jvim.12267
Data were presented in part at the 2012 American College of Veterinary Internal Medicine Forum, New Orleans, LA.
- Issue published online: 15 MAR 2014
- Article first published online: 26 DEC 2013
- Manuscript Accepted: 30 OCT 2013
- Manuscript Revised: 2 OCT 2013
- Manuscript Received: 18 JUN 2013
Published information regarding survival and long-term cardiac remodeling after patent ductus arteriosus (PDA) closure in dogs is limited.
To report outcome and identify prognostic variables in dogs with PDA, and to identify risk factors for persistent remodeling in dogs with a minimum of 12 months of follow-up after closure.
Five hundred and twenty client-owned dogs.
Retrospective review of medical records of 520 dogs with PDA. Outcome was determined by contacting owners and veterinarians. Dogs with PDA closure and ≥ 12 months of follow-up were asked to return for a re-evaluation.
In multivariable analysis of 506 dogs not euthanized at the time of diagnosis, not having a PDA closure procedure negatively affected survival (HzR = 16.9, P < .001). In 444 dogs undergoing successful PDA closure, clinical signs at presentation (HzR = 17, P = .02), concurrent congenital heart disease (HD) (HzR = 4.8, P = .038), and severe mitral regurgitation (MR) documented within 24 hours of closure (HzR = 4.5, P = .028) negatively affected survival. Seventy-one dogs with ≥ 12 months follow-up demonstrated a significant reduction in radiographic and echocardiographic measures of heart size (P = 0) and increased incidence of acquired HD (P = .001) at re-evaluation. Dogs with increased left ventricular size and low fractional shortening at baseline were more likely to have persistent remodeling at re-evaluation.
Conclusions and Clinical Importance
Patent ductus arteriosus closure confers important survival benefits and results in long-term reverse remodeling in most dogs. Clinical signs at presentation, concurrent congenital HD, and severe MR negatively affect survival. Increased left ventricular systolic dimensions and systolic dysfunction at baseline correlated significantly with persistent remodeling.