This study was supported by the University of Florida, College of Veterinary Medicine Resident Intramural Competitive Grants Program
Levetiracetam Rectal Administration in Healthy Dogs
Version of Record online: 13 JAN 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 2, pages 504–509, March/April 2014
How to Cite
Peters, R.K., Schubert, T., Clemmons, R. and Vickroy, T. (2014), Levetiracetam Rectal Administration in Healthy Dogs. Journal of Veterinary Internal Medicine, 28: 504–509. doi: 10.1111/jvim.12269
- Issue online: 15 MAR 2014
- Version of Record online: 13 JAN 2014
- Manuscript Accepted: 5 NOV 2013
- Manuscript Revised: 24 SEP 2013
- Manuscript Received: 5 APR 2013
Levetiracetam is used to manage status epilepticus (SE) and cluster seizures (CS) in humans. The drug might be absorbed after rectal administration and could offer a practical adjunct to rectal administration of diazepam in managing SE and CS.
Levetiracetam is rapidly absorbed after rectal administration in dogs and maintains target serum concentrations for at least 9 hours.
Six healthy privately owned dogs between 2 and 6 years of age and weighing 10–20 kg.
Levetiracetam (40 mg/kg) was administered rectally and blood samples were obtained immediately before (time zero) and at 10, 20, 40, 60, 90, 180, 360, and 540 minutes after drug administration. Dogs were observed for signs of adverse effects over a 24-hour period after drug administration.
CLEV at 10 minutes was 15.3 ± 5.5 μg/mL (mean, SD) with concentrations in the target range (5–40 μg/mL) for all dogs throughout the sampling period. Cmax (36.0 ± 10.7 μg/mL) and Tmax (103 ± 31 minutes) values were calculated and 2 disparate groups were appreciated. Dogs with feces in the rectum at the time of drug administration had lower mean Cmax values (26.7 ± 3.4 μg/mL) compared with those without (45.2 ± 4.4 μg/mL). Mild sedation was observed between 60 and 90 minutes without other adverse effects noted.
Conclusions and Clinical Importance
This study supports the use of rectally administered levetiracetam in future studies of clinical effectiveness in the management of epileptic dogs.