An abstract that includes results from this study was presented in part at the 2013 ACVIM Forum, Seattle, WA
Serum Adipokine Concentrations in Dogs with Naturally Occurring Pituitary-Dependent Hyperadrenocorticism
Article first published online: 26 DEC 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 2, pages 429–436, March/April 2014
How to Cite
Cho, K.-D., Paek, J., Kang, J.-H., Chang, D., Na, K.-J. and Yang, M.-P. (2014), Serum Adipokine Concentrations in Dogs with Naturally Occurring Pituitary-Dependent Hyperadrenocorticism. Journal of Veterinary Internal Medicine, 28: 429–436. doi: 10.1111/jvim.12270
- Issue published online: 15 MAR 2014
- Article first published online: 26 DEC 2013
- Manuscript Accepted: 5 NOV 2013
- Manuscript Revised: 25 SEP 2013
- Manuscript Received: 2 MAR 2013
- Research Foundation of Korea (NRF)
- Ministry of Science, ICT and Future Planning. Grant Number: 2013R1A1A1011113
- Cushing's disease;
An excess of intra-abdominal fat is observed frequently in dogs with hyperadrenocorticism (HAC). Adipokine dysregulation is a possible cause of complications related to visceral obesity, but little information is available on adipokine in dogs with naturally occurring HAC.
To examine the differences in the circulating adipokines concentrations in overweight dogs with and without pituitary-dependent HAC (PDH).
Thirty healthy dogs and 15 client-owned dogs with PDH.
Case–controlled observational study, which enrolled 15 overweight dogs diagnosed with PDH and 30 otherwise healthy dogs of similar body condition score. Nine of 15 dogs with PDH were treated with low-dose trilostane twice daily and reassessed after treatment.
The serum leptin (P < .0001) and insulin (P < .0001) concentrations were significantly higher in the PDH group (leptin, 22.8 ± 8.8 [mean ± SD]; insulin, 9.1 ± 6.1) than the healthy group (leptin, 4.9 ± 3.7; insulin, 1.9 ± 0.9). However, there were no significant differences in the adiponectin, resistin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and IL-18 levels between the 2 groups. In the PDH group, the serum cortisol concentrations had a linear association with the leptin concentrations, and there were significant decreases in the leptin (P = .0039) and insulin (P = .0039) levels after trilostane treatment. However, the leptin and insulin levels remained higher after trilostane treatment than in healthy control dogs with similar body condition score.
Conclusions and Clinical Importance
Hypercortisolemia in dogs with PDH might upregulate the circulating leptin levels. However, a large population-based study will be necessary to determine whether the upregulation of leptin is involved directly with the complications caused by HAC.