Work performed at the University of Minnesota, College of Veterinary Medicine, Veterinary Medical Center, Veterinary Diagnostic Laboratory, and Department of Veterinary Clinical Sciences, St. Paul, Minnesota. This research was presented, in part, as an abstract at the 2009 American College of Veterinary Internal Medicine Forum and Canadian Veterinary Medical Association Convention, Montreal, Quebec, Canada
Clinical Features, Intestinal Histopathology, and Outcome in Protein-Losing Enteropathy in Yorkshire Terrier Dogs
Article first published online: 27 JAN 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 2, pages 331–337, March/April 2014
How to Cite
Simmerson, S.M., Armstrong, P.J., Wünschmann, A., Jessen, C.R., Crews, L.J. and Washabau, R.J. (2014), Clinical Features, Intestinal Histopathology, and Outcome in Protein-Losing Enteropathy in Yorkshire Terrier Dogs. Journal of Veterinary Internal Medicine, 28: 331–337. doi: 10.1111/jvim.12291
- Issue published online: 15 MAR 2014
- Article first published online: 27 JAN 2014
- Manuscript Accepted: 26 NOV 2013
- Manuscript Revised: 27 SEP 2013
- Manuscript Received: 23 JUL 2013
- Endoscopic biopsy;
- Inflammatory bowel disease;
A poorly understood protein-losing enteropathy (PLE) disorder has been reported in Yorkshire Terrier dogs.
To describe clinical features, intestinal histopathology, and outcome in Yorkshire Terrier dogs with PLE, and to identify variables predictive of outcome.
Thirty client-owned Yorkshire Terrier dogs with PLE.
Retrospective study. Records of dogs with a diagnosis of PLE were reviewed. Intestinal histopathology was interpreted using the World Small Animal Veterinary Association gastrointestinal histopathology classification system. Discriminate analysis techniques were used to identify variables predictive of outcome.
Females outnumbered males (20/30). Median age was 7 years (range 1–12). Common clinical signs were diarrhea (20/30), vomiting (11), ascites and abdominal distension (11), and respiratory difficulty (8). Histopathologic abnormalities included villous lymphatic dilatation, crypt lesions, villous stunting, and variable increases in cellularity of the lamina propria. All dogs were treated with glucocorticoids. Of 23 dogs with long-term follow-up, 9 had complete, and 3 had partial, resolution of signs, and 11 failed to respond to treatment. Median survival of responders was 44 months and of nonresponders was 12 months, with 4 dogs experiencing peracute death. Vomiting, monocytosis, severity of hypoalbuminemia, low blood urea nitrogen concentration, and villous blunting were predictive of survival <4 months.
In addition to classic GI signs, Yorkshire Terriers with PLE often show clinical signs associated with hypoalbuminemia and low oncotic pressure. Lymphatic dilatation, crypt lesions, and villous stunting are consistent histopathologic findings. Clinical outcomes are variable, but many dogs experience remission of clinical signs and prolonged survival.