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Table S1. Summary of treatment delays (TDs) seen in 470 dogs with appendicular OSA treated with limb amputation and prescribed carboplatin and doxorubicin-based chemotherapy protocols.

Table S2. Factors associated with disease-free interval (DFI), survival time (ST), or both on univariable analysis (per-protocol analysis).

Table S3. The effect of choice of chemotherapy protocol on disease-free interval (DFI) and survival times (STs) for the per-protocol analysis.

Figure S1. Trends in adverse events by chemotherapy protocol.

Figure S2. Trends in treatment delays by chemotherapy protocol.

Figure S3. Kaplan–Meyer curve for DFI for single agent carboplatin protocols (CARBO4 and CARBO6) compared to single agent doxorubicin protocols (DOX5.2 and DOX5.3) (modified intent-to-treat analysis).

Figure S4. Kaplan–Meyer curve for ST for single agent carboplatin protocols compared to single agent doxorubicin protocols (modified intent-to-treat analysis).

Figure S5. Kaplan–Meyer curve for DFI for all protocols (modified intent-to-treat analysis).

Figure S6. Kaplan–Meyer curve for ST for all protocols (modified intent-to-treat analysis).

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