Environmental Exposures and Airway Inflammation in Young Thoroughbred Horses
Article first published online: 12 MAR 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 3, pages 918–924, May/June 2014
How to Cite
Ivester, K.M., Couëtil, L.L., Moore, G.E., Zimmerman, N.J. and Raskin, R.E. (2014), Environmental Exposures and Airway Inflammation in Young Thoroughbred Horses. Journal of Veterinary Internal Medicine, 28: 918–924. doi: 10.1111/jvim.12333
- Issue published online: 28 APR 2014
- Article first published online: 12 MAR 2014
- Manuscript Accepted: 21 JAN 2014
- Manuscript Revised: 6 DEC 2013
- Manuscript Received: 21 AUG 2013
- SVM Internal Competitive Small and Agricultural Animal Disease Research Funds Program
- Bronchoalveolar lavage;
Inflammatory airway disease (IAD) in horses is a widespread, performance-limiting syndrome believed to develop in response to inhaled irritants in the barn environment.
To evaluate changes in bronchoalveolar lavage fluid (BALF) cytology and exposure to particulates, endotoxin, and ammonia during horses' first month in training.
Forty-nine client-owned 12- to 36-month-old Thoroughbred horses entering race training.
In this prospective cohort study, a convenience sample of horses was assigned to be fed hay from a net (n = 16), whereas the remaining horses were fed hay from the ground (n = 33). BALF was collected at enrollment and after 14 and 28 days in training. Respirable particulate, inhalable particulate, respirable endotoxin, and ammonia concentrations were measured at the breathing zone of each horse weekly.
Median respirable particulates were significantly higher when horses were fed from hay nets than when fed hay from the ground (hay net 0.28 mg/m3, no hay net 0.055 mg/m3, P < .001). Likewise, inhalable particulate (hay net 8.3 mg/m3, no hay net 3.3 mg/m3, P = .0064) and respirable endotoxin (hay net 173.4 EU/m3, no hay net 59.2 EU/m3, P = .018) exposures were significantly higher when horses were fed from hay nets. Feeding hay from a net resulted in significantly higher BALF eosinophil proportions over time (P < .001). BALF eosinophils were significantly related to respirable particulate exposure (14 days in training rs = 0.37, P = .012, 28 days in training, rs = 0.38, P = .017).
Conclusions and Clinical Importance
Pulmonary eosinophilic inflammation develops in response to respirable particulate exposure in young Thoroughbreds, indicating a potential hypersensitivity to inhaled particulate allergens.