These data were presented, in part, in abstract form at the 2013 ACVIM Forum in Seattle WA
Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune-Mediated Polyarthropathy
Version of Record online: 3 APR 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 3, pages 905–911, May/June 2014
How to Cite
Foster, J.D., Sample, S., Kohler, R., Watson, K., Muir, P. and Trepanier, L.A. (2014), Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune-Mediated Polyarthropathy. Journal of Veterinary Internal Medicine, 28: 905–911. doi: 10.1111/jvim.12351
- Issue online: 28 APR 2014
- Version of Record online: 3 APR 2014
- Manuscript Accepted: 24 FEB 2014
- Manuscript Revised: 29 OCT 2013
- Manuscript Received: 23 JUL 2013
- American Kennel Club Canine Health Foundation
- C-reactive protein;
Immune-mediated polyarthopathy (IMPA) is common in dogs, and is monitored by serial arthrocenteses.
Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and CXCL8 (interleukin-8) would serve as noninvasive markers of joint inflammation in IMPA.
Nine client-owned dogs with idiopathic IMPA; 6 healthy controls.
Prospective study. Plasma CRP, IL-6, and CXCL8 were measured by ELISA at baseline, 2, and 4 weeks during treatment with prednisone at 50 mg/m2/day. Arthrocenteses, the canine brief pain inventory (CBPI), and accelerometry collars were used to assess joint inflammation, lameness, and mobility at all 3 time points.
C-reactive protein concentrations were higher in IMPA dogs (median 91.1 μg/mL, range 76.7–195.0) compared with controls (median <6.3 μg/mL, <6.3–13.7; P = .0035), and were significantly lower at week 2 (10.6 μg/mL, <6.3–48.8) and week 4 (<6.3 μg/mL, <6.3–24.4; P < .001).
C-reactive protein was correlated with median CBPI scores (r = 0.68; P = .0004), joint cellularity (r = 0.49, P = .011), and mobility by accelerometry (r = −0.42, P = .048). Plasma IL-6 concentrations were also higher in IMPA dogs (median 45.9 pg/mL), compared with controls (median <15.7 pg/mL; P = .0008). IL-6 was lower in IMPA dogs by week 4 (<15.7 pg/mL; P = .0099), and was modestly correlated with CBPI scores (r = 0.47, P = .023). CXCL8 did not differ significantly between IMPA and healthy dogs.
Plasma CRP and IL-6 might be useful surrogate markers of synovial inflammation and disease activity in dogs with IMPA.