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Keywords:

  • Cardiomyopathy;
  • Congestive heart failure;
  • Nutrition

Background

Diet might influence progression of hypertrophic cardiomyopathy (HCM).

Objective

To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.

Animals

Twenty-nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.

Methods

Randomized, placebo-controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.

Results

There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, = .760; Group B, = .475; Group C, = .066) or interventricular septal thickness in diastole (Group A, = .528; Group B, = .221; Group C, = .097). Group A had significant increases in BUN (= .008) and cholesterol (= .021), while Group B had significant increases in BUN (= .008), cholesterol (= .007), and triglycerides (= .005), and significant decreases in NT-proBNP (= .013) and hs-troponin I (= .043). Group C had significant decreases in body weight (= .021), left atrial dimension (= .035), interventricular septal thickness in systole (= .038), and liver enzymes (= .034–.038).

Conclusions and Clinical Importance

These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.