Presented, in part, at the 2013 ACVIM Forum, Seattle, WA
A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy
Article first published online: 3 APR 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 3, pages 847–856, May/June 2014
How to Cite
Freeman, L.M., Rush, J.E., Cunningham, S.M. and Bulmer, B.J. (2014), A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy. Journal of Veterinary Internal Medicine, 28: 847–856. doi: 10.1111/jvim.12352
- Issue published online: 28 APR 2014
- Article first published online: 3 APR 2014
- Manuscript Accepted: 24 FEB 2014
- Manuscript Revised: 20 DEC 2013
- Manuscript Received: 20 AUG 2013
- Barkley Fund
- Congestive heart failure;
Diet might influence progression of hypertrophic cardiomyopathy (HCM).
To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.
Twenty-nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.
Randomized, placebo-controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.
There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT-proBNP (P = .013) and hs-troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038).
Conclusions and Clinical Importance
These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.