Preliminary results were presented as an oral presentation at the 26th Annual Symposium of the ESVN-ECVN, Paris, September 26–28, 2013.
Corpus Callosal Abnormalities in Dogs
Version of Record online: 19 MAY 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 4, pages 1275–1279, July/August 2014
How to Cite
Gonçalves, R., Volk, H., Smith, P.M., Penderis, J., Garosi, L., MacKillop, E., de Stefani, A., Cherubini, G. and McConnell, J.F. (2014), Corpus Callosal Abnormalities in Dogs. Journal of Veterinary Internal Medicine, 28: 1275–1279. doi: 10.1111/jvim.12371
- Issue online: 15 JUL 2014
- Version of Record online: 19 MAY 2014
- Manuscript Accepted: 8 APR 2014
- Manuscript Revised: 25 FEB 2014
- Manuscript Received: 14 JAN 2014
- Corpus callosum;
Corpus callosal abnormalities (CCA) in dogs have been only sporadically reported and are poorly characterized.
To describe the clinical presentation and magnetic resonance imaging (MRI) characteristics of dogs with CCA.
Fifteen client-owned dogs.
Retrospective study. Records of the contributing institutions were reviewed to identify dogs diagnosed with malformations affecting the corpus callosum (CC); cases in which the CCA was thought to be secondary were excluded.
The most represented breeds were Staffordshire Bull Terriers (5/15) and Miniature Schnauzers (3/15; n = 3, 20%) and the mean age at time of presentation of 19 months (range 3–81 months). The clinical signs most commonly reported were adipsia/hypodipsia with associated hypernatremia (12/15), tremors (6/15), and seizures (6/15). Review of the MR images revealed that 10 dogs had absence of the rostral CC and hypoplasia of the caudal portion, 4 dogs had a diffusely hypoplastic and dysplastic CC, and 1 dog had a diffusely hypoplastic CC. In 14 cases, there was abnormal cortical development with fusion of the ventral frontal lobes and part of the diencephalon, indicating lobar holoprosencephaly.
Conclusions and Clinical Importance
Previous literature has mainly associated CCA with adipsia and only 12 of 15 dogs in the current series demonstrated this abnormality. There are different degrees of the malformation but in 10 dogs the rostral portion of the CC is most severely affected. Fourteen dogs have simultaneous fusion of the midline structures rostral to the CC; this region has several structures involved in thirst regulation and might explain this derangement.