This study was carried out at the Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Denmark, from 2010 to 2013.
Cardiac Troponin I and T as Prognostic Markers in Cats with Hypertrophic Cardiomyopathy
Article first published online: 23 JUL 2014
Copyright © 2014 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 28, Issue 5, pages 1485–1491, September/October 2014
How to Cite
Langhorn, R., Tarnow, I., Willesen, J.L., Kjelgaard-Hansen, M., Skovgaard, I.M. and Koch, J. (2014), Cardiac Troponin I and T as Prognostic Markers in Cats with Hypertrophic Cardiomyopathy. Journal of Veterinary Internal Medicine, 28: 1485–1491. doi: 10.1111/jvim.12407
Part of the study was funded through research grants from the Fund of Scientific Studies in Companion Animals, Denmark, and Agria & SKK's Research Fund for Companion Animals, Sweden.
- Issue published online: 1 OCT 2014
- Article first published online: 23 JUL 2014
- Manuscript Accepted: 29 MAY 2014
- Manuscript Revised: 8 MAY 2014
- Manuscript Received: 7 AUG 2013
- Companion animals;
- Myocardial injury;
- Prognostic significance
Myocardial injury detected by cardiac troponin I and T (cTnI and cTnT) in cardiac disease is associated with increased risk of death in humans and dogs.
Presence of myocardial injury predicts long-term death in cats with hypertrophic cardiomyopathy (HCM), and ongoing myocardial injury reflects change in left ventricular wall thickness over time.
Thirty-six cats with primary HCM.
Prospective cohort study. Cats with HCM were included consecutively and examined every 6 months. Echocardiography, ECG, blood pressure, and serum cTnI and cTnT were evaluated at each visit. Cox proportional hazards regression analysis was performed to evaluate prognostic potential of serum troponin concentrations at admission and subsequent examinations. Correlations were used to examine associations between troponin concentrations and cardiac hypertrophy.
Troponin concentrations at admission were median [range] 0.14 [0.004–1.02] ng/mL for cTnI, and 13 [13–79.5] ng/L for cTnT. Both were prognostic for death (P = .032 and .026) as were the last available concentrations of each (P = .016 and .003). The final cTnT concentration was a significant predictor of death even when adjusting for the admission concentration (P = .043). In a model containing both markers, only cTnT remained significant (P = .043). Left ventricular free wall thickness at end-diastole (LVFWd) at admission was correlated with cTnI at admission (r = 0.35, P = .035), however no significant correlations (r = 0.2–0.31, P = .074–.26) were found between changes in troponin concentrations and left ventricular thickness over time.
Conclusions and Clinical Importance
Myocardial injury is part of the pathophysiology leading to disease progression and death. Low sensitivities and specificities prevent outcome prediction in individual cats.