Pharmacokinetics of macrolides in foals
Article first published online: 22 OCT 2012
© 2012 Blackwell Publishing Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 36, Issue 1, pages 1–13, February 2013
How to Cite
Villarino, N., Martín-Jiménez, T Pharmacokinetics of macrolides in foals. J. vet. Pharmacol. Therap. 36, 1…13.
- Issue published online: 15 JAN 2013
- Article first published online: 22 OCT 2012
- Manuscript Accepted: 13 AUG 2012
- Manuscript Revised: 10 AUG 2012
- Manuscript Received: 16 NOV 2011
Macrolides are used for treatment of pneumonia and extrapulmonary conditions caused by Rhodococcus equi. In foals, macrolides have an extraordinary capacity to accumulate in different lung tissue compartments. These drugs show unique pharmacokinetic features such as rapid and extensive distribution and long persistence in pulmonary epithelial lining fluid (PELF) and bronchoalveolar lavage (BAL) cells from foals. This article reviews the pharmacokinetic characteristics of erythromycin, azithromycin, clarithromycin, tulathromycin, telithromycin, gamithromycin, and tilmicosin in foals, with emphasis on PELF and BAL cell concentrations.