Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation
Article first published online: 30 OCT 2012
© 2012 John Wiley & Sons Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 36, Issue 4, pages 399–407, August 2013
How to Cite
Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation. J. vet. Pharmacol. Therap. 36, 399–407., , , , , .
- Issue published online: 4 JUL 2013
- Article first published online: 30 OCT 2012
- Manuscript Accepted: 14 SEP 2012
- Manuscript Received: 18 JUN 2012
- NCSU Clinical Pharmacology Laboratory
Ronidazole (RDZ) is the only known effective treatment for feline diarrhea caused by Tritrichomonas foetus. This study aimed to develop guar gum-coated colon-targeted tablets of RDZ and to determine the pharmacokinetics of this delayed-release formulation in cats. Guar gum-coated tablets were administered orally once to five healthy cats (mean dose 32.3 mg/kg). The tablets were then administered once daily for 5 days to four cats (mean dose 34.5 mg/kg), and absorption studies repeated on day 5. Plasma was collected and analyzed for RDZ concentration, and pharmacokinetic noncompartmental and deconvolution analysis were performed on the data. There was negligible RDZ release until after 6 h, and a delayed peak plasma concentration (mean Cmax 28.9 μg/mL) at approximately 14.5 h, which coincides with colonic arrival in cats. Maximum input rate (mg/kg per hour) occurred between 6 and 16 h. This delayed release of ronidazole from guar gum-coated tablets indicates that release of RDZ may be delayed to deliver the medication to a targeted area of the intestine. Repeated dosing with guar gum tablets to steady-state did not inhibit drug bioavailability or alter the pharmacokinetics. Such targeted RDZ drug delivery may provide improved efficacy and reduce adverse effects in cats.