The study was performed at the University of Tennessee, College of Veterinary Medicine, Knoxville, TN, USA.
Evaluation of regional limb perfusion with erythromycin using the saphenous, cephalic, or palmar digital veins in standing horses
Version of Record online: 14 DEC 2012
© 2012 John Wiley & Sons Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 36, Issue 5, pages 434–440, October 2013
How to Cite
Evaluation of regional limb perfusion with erythromycin using the saphenous, cephalic, or palmar digital veins in standing horses. J. vet. Pharmacol. Therap. 36, 434–440., , , , ,
- Issue online: 6 SEP 2013
- Version of Record online: 14 DEC 2012
- Manuscript Accepted: 2 NOV 2012
- Manuscript Received: 20 MAY 2012
- Tennessee Equine Veterinary Research Organization (TEVRO)
Vol. 37, Issue 1, 103, Version of Record online: 10 JAN 2014
There are no reported studies evaluating the use of erythromycin for regional limb perfusion (RLP) in horses. Our hypothesis was that using the cephalic and saphenous veins for RLP will enable delivery of therapeutic concentrations of erythromycin to the distal limb. Nineteen healthy horses participated in the study. The cephalic, saphenous or palmar digital (PD) vein was used to perfuse the limb with erythromycin. Synovial samples were collected from the metacarpo/metatarso-phalangeal (MCP/MTP) joint and blood samples were collected from the jugular vein. Maximum concentration (Cmax) of erythromycin in the MCP joint using the cephalic vein was 113 mg/L. The Cmax of erythromycin in the MTP joint using the saphenous vein was 38 mg/L. Erythromycin administered using the PD vein was not detectable in the MCP/MTP joint of four of six horses. Concentrations of erythromycin achieved in the synovial fluid of the MCP/MTP joint were between 152 and 452 times the minimal inhibitory concentration (MIC) for Rhodococcus equi (R. equi). In conclusion, the results indicate that when using the saphenous or cephalic veins for RLP, therapeutic concentrations of erythromycin in the MTP/MTP joint can be consistently reached.