Challenges and opportunities in polymer technology applied to veterinary medicine

Authors

  • J. M. Bermudez,

    1. Instituto de Investigaciones para la Industria Química (INIQUI), Universidad Nacional de Salta, CONICET, Salta, Argentina
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  • A. G. Cid,

    1. Instituto de Investigaciones para la Industria Química (INIQUI), Universidad Nacional de Salta, CONICET, Salta, Argentina
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  • M. V. Ramírez-Rigo,

    1. Planta Piloto de Ingeniería Química (PLAPIQUI), Universidad Nacional del Sur, CONICET, Bahía Blanca, Argentina
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  • D. Quinteros,

    1. Facultad de Ciencias Químicas, Departamento de Farmacia, Unidad de investigación y desarrollo en tecnología farmacéutica (UNITEFA), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina
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  • A. Simonazzi,

    1. Instituto de Investigaciones para la Industria Química (INIQUI), Universidad Nacional de Salta, CONICET, Salta, Argentina
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  • S. Sánchez Bruni,

    1. Centro de Investigación Veterinaria de Tandil (CIVETAN), Universidad Nacional del Centro de la Pcia. de Buenos Aires, CONICET, Tandil, Argentina
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  • S. Palma

    Corresponding author
    1. Facultad de Ciencias Químicas, Departamento de Farmacia, Unidad de investigación y desarrollo en tecnología farmacéutica (UNITEFA), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina
    • Santiago Palma, Faculty of Chemical Science, Department of Pharmacy, Haya de la Torre esq. Medina Allende, Ciudad Universitaria, 5000, Córdoba, Argentina. E-mail: sdpalma@fcq.unc.edu.ar

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Abstract

An important frontier in the administration of therapeutic drugs to veterinary species is the use of different polymers as drug delivery platforms. The usefulness of polymers as platforms for the administration of pharmaceutical and agricultural agents has been clearly recognized in the recent decades. The chemical versatility of polymers and the wide range of developed controlled-release strategies enhance the possibilities for the formulation of active molecules. In particular, the veterinary area offers opportunities for the development of novel controlled-release drug delivery technologies adapted to livestock or companion animal health needs. In some cases, it also allows to improve profitability in meat production or to meet the safety criteria related to drug residues. A number of factors affect the selection of polymers and subsequent properties of the controlled-release drug delivery system. However, their selection also dictates the release kinetics of the drug from the delivery system. Such choices are therefore crucial as they affect the success and potential of the delivery system for achieving the therapeutic goals of the veterinarian. It is the intention of this review to give an overview of the most relevant polymers, which are used or have been tested as drug delivery release rate modifiers in the veterinary field. The article highlights some recent developments focusing on their advantages and applications and analyzes the future direction of the scientific and technological advancements in this area.

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