The characterization of a thermostable and cambialistic superoxide dismutase from Thermus filiformis (pages 40–46)
F. Mandelli, J.P.L. Franco Cairo, A.P.S. Citadini, F. Büchli, T.M. Alvarez, R.J. Oliveira, V.B.P. Leite, A.F. Paes Leme, A.Z. Mercadante and F.M. Squina
Version of Record online: 12 APR 2013 | DOI: 10.1111/lam.12071
Significance and Impact of the Study: This manuscript describes the expression and characterization of a superoxide dismutase (SOD) from Thermus filiformis with thermophilic and cambialistic characteristics. The SODs are among the most potent antioxidants known in nature, and their stability and pharmacokinetics can vary widely in accordance to their biological source. Although the currently clinical research work has been focused on human and bovine SODs, alternative sources may become more biotechnological attractive in the near future. Our study brings new insights for the research field of antioxidant enzymes with potential application on pharmaceutical, cosmetics and food formulations.