Interactions of protamine with the marine bacterium, Pseudoalteromonas sp. NCIMB 2021 (pages 225–230)
A. Pustam, C. Smith, C. Deering, K.M.T. Grosicki, T.Y. Leng, S. Lin, J. Yang, D. Pink, T. Gill, L. Graham, D. Derksen, C. Bishop, M.E. DeMont, R.C. Wyeth and T. Smith-Palmer
Version of Record online: 11 NOV 2013 | DOI: 10.1111/lam.12177
Significance and Impact of the Study: Protamine is a cationic antimicrobial peptide (CAP), which is active against a variety of bacteria. This is the first in-depth study of the interaction of protamine with a marine bacterium, Pseudoalteromonas sp. NCIMB 2021. Our results show that protamine is only active in seawater in the absence of divalent cations. In the presence of the divalent cations, Mg2+ and Ca2+, protamine enhances the growth of Pseudoalteromonas sp. NCIMB 2021 and produces chains rather than individual cells. These are important considerations when deciding on applications for protamine and in terms of understanding its mechanism of action.