Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
Article first published online: 14 NOV 2012
© 2012 John Wiley & Sons A/S
Volume 33, Issue 1, pages 94–103, January 2013
How to Cite
Pascarella, S., Clément, S., Dill, M. T., Conzelmann, S., Lagging, M., Missale, G., Neumann, A. U., Pawlotsky, J.-M., Zeuzem, S., Rubbia-Brandt, L., Bochud, P.-Y. and Negro, F. (2013), Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C. Liver International, 33: 94–103. doi: 10.1111/liv.12031
- Issue published online: 10 DEC 2012
- Article first published online: 14 NOV 2012
- Accepted manuscript online: 30 OCT 2012 07:50AM EST
- Manuscript Accepted: 4 OCT 2012
- Manuscript Received: 29 FEB 2012
- Swiss National Science Foundation. Grant Numbers: 320000-116544, 314730-130498
- Leenaards Foundation
- Essex Chemie AG
- HCV ;
- hepatitis C;
- RVR ;
- SOCS ;
Antiviral treatment of chronic hepatitis C is not invariably successful, costly and associated with serious side-effects, and therefore should be indicated only when the chances of benefitting patients exceed the potential risks. The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting.
We measured the intrahepatic SOCS1, SOCS3 and SOCS7 mRNA levels in 107 chronic hepatitis C patients and assessed their clinical and histological correlates with the virological response to therapy and with some factors known for affecting treatment outcome.
By multivariate analysis, SOCS1, SOCS3 and SOCS7 mRNA levels were not associated with rapid or sustained virological response. Similarly, no association was found between the levels of any intrahepatic SOCS mRNA and those of the homeostasis model assessment of insulin resistance. Conversely, SOCS1 (OR 2.185, 95% CI 1.223–3.906, P=0.0083) and SOCS3 (OR 40.601, 95% CI 2.357–699.25, P=0.0108) mRNA level (but not SOCS7), together with age (OR 1.156, 95% CI 1.049–1.275, P=0.0036), were independently associated with cirrhosis.
Intrahepatic SOCS1, SOCS3 and SOCS7 mRNA levels do not predict virological response to therapy in chronic hepatitis C. The association between SOCS1, SOCS3 and cirrhosis warrants further study.