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Fig. S1. Portal macrophages are more abundant than neutrophils in chronic HCV infection. Immunolabelling with neutrophil elastase (neutrophils) and CD163 (MΦ). (Data are represented as +SEM, P < 0.05, ***P < 0.001).

Fig. S2. Macrophage and MMP-9 localisation in biliary fibrosis. (A) Representative biliary fibrosis section immunolabelled with CD163 and K7 confirmed the presence of MΦ (brown) in close proximity to the DR (pink). (B) Triple-labelled immunofluorescence with CD163 (red), MMP-9 (green) and K7 (pink) confirmed that portal macrophages did not express MMP-9. (Original magnifications: A ×200, B ×250).

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