Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C
Article first published online: 13 DEC 2012
© 2012 John Wiley & Sons A/S
Volume 33, Issue 4, pages 569–579, April 2013
How to Cite
Liver Int. 2013: 33: 569–579
- Issue published online: 12 MAR 2013
- Article first published online: 13 DEC 2012
- Accepted manuscript online: 12 NOV 2012 06:20AM EST
- Manuscript Accepted: 6 NOV 2012
- Manuscript Revised: 14 SEP 2012
- Manuscript Received: 31 MAY 2012
- National Health and Medical Research Council of Australia. Grant Number: APP1003108
- Queensland Government's Smart State Health and Medical Research Fund
- Princess Alexandra Hospital Research and Development Foundation
- Sasakawa Foundation
Fig. S1. Portal macrophages are more abundant than neutrophils in chronic HCV infection. Immunolabelling with neutrophil elastase (neutrophils) and CD163 (MΦ). (Data are represented as +SEM, P < 0.05, ***P < 0.001).
Fig. S2. Macrophage and MMP-9 localisation in biliary fibrosis. (A) Representative biliary fibrosis section immunolabelled with CD163 and K7 confirmed the presence of MΦ (brown) in close proximity to the DR (pink). (B) Triple-labelled immunofluorescence with CD163 (red), MMP-9 (green) and K7 (pink) confirmed that portal macrophages did not express MMP-9. (Original magnifications: A ×200, B ×250).
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