- Top of page
- Problems in the therapeutic strategy
- No role for antivirals against HBV
- Treatment with standard IFN
- Treatment with pegylated IFNs
- Future therapies
- Liver transplantation
Interferon is the only therapy for chronic hepatitis D. Nucleos(t)ides are not effective against the helper hepatitis B virus. The current therapeutic recommendation is a weekly dose of pegylated interferon (PEG-IFN)-α, for 12–18 months. Serum HDV-RNA only becomes undetectable after 6 months of therapy in about a quarter of the patients. Hepatitis D virus (HDV) may relapse in patients if they remain HBsAg positive. Although the end-point of therapy is the clearance of the HBsAg, this is seldom achieved. Current management of HDV patients is based on standard practices which should be pragmatic and individualized.