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Keywords:

  • antiviral therapy;
  • hepatitis C;
  • non-nucleoside polymerase inhibitors;
  • nucleoside polymerase inhibitors

Abstract

The characterization of the viral life cycle facilitated the development of directly acting antiviral drugs. Among those, several inhibitors of the viral RNA-dependent RNA polymerase have proven effectiveness in clinical trials. The characteristics of different nucleos(t)ide and non-nucleoside polymerase inhibitors, as well as their clinical applications and combinations with other classes of directly acting antiviral drugs are reviewed herein.