Fig. S1. Isobologram analysis showing the additive effects of the combination considering the IC50 values. (A) Interaction RAD001/BEZ235. (B) Interaction RAD001/BKM120

Fig. S2. Ki67, pHis3 and TUNEL staining on mice receiving (A) PI3K/mTOR inhibitors and (B) PI3K/mTOR inhibitors and cisplatin.

Fig. S3. Assessment of cell cycle involvement and apoptosis rate by PI3K/mTOR inhibitors and chemotherapeutic drugs. Huh7 cells were treated with IC50 of RAD001, BEZ235 and BKM120 alone or in combination with cisplatin for 24 h and either cell-cycle progression (A) or apoptotic cells (B) were analysed.

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