Hospital mortality over time in patients with specific complications of cirrhosis

Authors


Correspondence

Mercedes Vergara, Digestive Disease Unit, Corporació Sanitària Parc Taulí, Parc Taulĺ s/n, 08208 Sabadell, Barcelona

Tel: +34 937231010 (ext 20280)

Fax: +34 937160646

e-mail: mvergara@tauli.cat

Abstract

Hospital mortality secondary to cirrhosis is high.

Aim

To evaluate hospital mortality in patients admitted for specific complications of cirrhosis over time.

Material and methods

Registry-data from Administrative Inpatient Dataset of acute care hospitals were collected at discharge from 2003 to 2010. Inclusion criteria were as follows: hospital admissions where one of the diagnoses was cirrhosis and the reason for admission was a specific complication of cirrhosis (ascites, encephalopathy, hepatorenal syndrome and haemorrhage from varices, bacterial spontaneous peritonitis). Analysis of variance was used for comparisons of quantitative variables and Chi-square for qualitative variables. Logistic regression was performed to identify the risk factors associated with hospital mortality; the Hosmer and Lemeshow test was applied to evaluate calibration and the ROC curve for discrimination respectively.

Results

A total of 12,671 hospital admissions were analysed; 67.7% were men. Mean hospitalization stay was 10.9 (SD 9.2) days and the most frequent causes were encephalopathy (44.2%) and ascites (30.9%). Global hospital mortality was 11.6%. Logistic regression showed that once all factors had been adjusted, hepatorenal syndrome conveyed the highest risk for death (49.2%; OR = 8.1(95%CI:6.6–9.9). Risk of death was also increased by associated comorbidities and older age. Hospital mortality in the period 2006–2010 was 27% inferior to the period 2003–2005. The area under the ROC curve (AUROC) was 0.77 (95%CI 0.76–0.78).

Conclusions

Hospital mortality as a result of specific complications of cirrhosis is high, but has been declining in recent years.

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