Association between the hepatitis B and C viruses and metabolic diseases in patients stratified by age



Wen-Cheng Li, Department of Occupation Medicine, Keelung Chang-Gung Memorial Hospital

No. 222, Maijin Rd., 20441 Keelung, Taiwan

Tel: +886 3 3281 200 #3614

Fax: +886 3 3287 715




Hepatitis B/C viruses cause liver disease and metabolic disturbances.


The purpose of this study was to evaluate the association between hepatitis B/C infection and metabolic syndrome (MS).


In total, 26 305 subjects were included in this multicentre, cross-sectional study. Systolic and diastolic blood pressures, body mass index and waist circumference were measured. Total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, fasting blood glucose and uric acid were determined, and hepatitis B serum antigen (HBsAg) and anti-HCV antibodies were assayed using commercial kits.


MS was diagnosed in 2712 (23.0%) females, including 131 and 166 positive for HBsAg and anti-HCV respectively. In the men, 4594 (31.6%) were diagnosed with MS, including 326 positive for HBsAg and 131 positive for anti-HCV. No significant difference in the prevalence of MS was identified in any group, except men and women >45 years who were anti-HCV positive. Various metabolic alterations in both men and women >45 years were noted, including waist circumference, body mass index, fasting blood glucose and systolic and diastolic blood pressure. Notably, high- and low-density lipoproteins were significantly lower in positive subjects compared to those weakly positive and/or negative for anti-HCV.


There were obvious metabolic derangements in patients coinflicted with MS and hepatitis C infections, particularly those >45 years of age. There is a pressing need to identify strategies to improve/resolve metabolic derangements to maximize sustained virological response rates in patients infected with HCV (and potentially HBV).