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Fig. S1. Level of fucosylated GSLs expressed by HCC and peritumoral tissues. Ion abundance of fucosylated GSLs was quantified as the percentage of total cellular GSL. Fucosylated GSLs were 3.3-fold more abundant in HCC samples than in paired peritumoral tissues from 32 patients (*< 0.05 by Student t-test). Bars indicate means.

Fig. S2. Decomposition pathway of aberrant pentosaccharide. The decomposition pathway of a representative ion (m/z 1634). Type I H: Fucα2Galβ3GlcNAcβ3Galα4Glcβ1Cer; Type II H: Fucα2Galβ4GlcNAcβ3Galα4Glcβ1Cer; Lex: Fucα3(Galβ4)GlcNAcβ3Galβ4Glcβ1Cer; Lea: Fucα4(Galβ3)GlcNAcβ3Galβ4Glcβ1Cer.

Fig. S3. Decomposition pathway of Leb and Ley. The decomposition pathway of a representative ion (m/z 1808). Leb: Fucα2Galβ3(Fucα4)GlcNAcβ3Galα4Glcβ1Cer; Ley: Fucα2Galβ4(Fucα3)GlcNAcβ3Galα4Glcβ1Cer.

Fig. S4. Decomposition pathway of Globo H. The decomposition pathway of a representative ion (m/z 1838). Globo H: Fucα2Galβ3GalNAcβ3Galα4Galβ4Glcβ1Cer.

Fig. S5. Analysis of a standard Globo H. Analysis of a Globo H standard by MALDI-TOF MS-MS. (A), specific fragment ions at m/z 443 and 660 and (B), the decomposition pathway of Globo H standard.

liv12265-sup-0002-TableS1-S3.docWord document83K

Table S1. Expression level of three groups of fucosylated GSLs in HCC and peritumoral tissues.

Table S2. Globo H expression in HCC and peritumoral tissues.

Table S3. Expression of Fucosyltransferase 1 and 2 in HCC and paired peritumoral tissues.

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