Cirrhosis and Liver Failure
Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients
Article first published online: 28 AUG 2013
© 2013 The Authors. Liver International published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 34, Issue 5, pages 700–706, May 2014
How to Cite
Liver Int. 2014: 34: 700–706
- Issue published online: 8 APR 2014
- Article first published online: 28 AUG 2013
- Accepted manuscript online: 2 AUG 2013 07:56AM EST
- Manuscript Accepted: 24 JUL 2013
- Manuscript Received: 24 APR 2013
- Ministry of Health, Labor and Welfare, Japan. Grant Number: H20-SHINKO-IPPAN-002
- influenza A(H1N1)pdm09 vaccine;
- liver function;
- risk factors
Background & Aims
To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C.
We conducted a hospital-based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV-RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records.
During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7).
Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.