Incidence and mortality trends for biliary tract cancers in Austria

Authors

  • Matthias Pinter,

    1. Division of Gastroenterology & Hepatology and Comprehensive Cancer Center, AKH & Medical University of Vienna, Vienna, Austria
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    • Vienna Liver Cancer Study Group.
  • Florian Hucke,

    1. Division of Gastroenterology & Hepatology and Comprehensive Cancer Center, AKH & Medical University of Vienna, Vienna, Austria
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    • Vienna Liver Cancer Study Group.
  • Nadine Zielonke,

    1. Austrian National Cancer Registry, Statistics Austria, Vienna, Austria
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  • Thomas Waldhör,

    1. Department of Epidemiology, Medical University of Vienna, Vienna, Austria
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  • Michael Trauner,

    1. Division of Gastroenterology & Hepatology and Comprehensive Cancer Center, AKH & Medical University of Vienna, Vienna, Austria
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  • Markus Peck-Radosavljevic,

    1. Division of Gastroenterology & Hepatology and Comprehensive Cancer Center, AKH & Medical University of Vienna, Vienna, Austria
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    • Vienna Liver Cancer Study Group.
  • Wolfgang Sieghart

    Corresponding author
    1. Division of Gastroenterology & Hepatology and Comprehensive Cancer Center, AKH & Medical University of Vienna, Vienna, Austria
    • Correspondence

      Wolfgang Sieghart, MD

      AKH & Medizinische Universität Wien, Klinik Innere Medizin III, Abteilung Gastroenterologie & Hepatologie, Währinger Gürtel 18–20, A-1090 Wien, Austria

      Tel: +43 1 40400 6589

      Fax: +43 1 40400 4735

      e-mail: wolfgang.sieghart@meduniwien.ac.at

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    • Vienna Liver Cancer Study Group.

Abstract

Background & Aims

The epidemiology of biliary tract cancers (BTC) varies between geographical regions and has changed over time globally. We investigated the incidence and mortality trends of patients diagnosed with BTC over a 20-year period in Austria.

Methods

Patients diagnosed with intrahepatic (iCCC)/extrahepatic cholangiocarcinoma (eCCC), ampullary carcinoma, gall bladder carcinoma (GBC), overlapping lesions or unspecified carcinomas of the biliary tract and liver were included. Data on age-adjusted incidence were obtained from the Austrian National Cancer Registry which compiles data on all newly diagnosed cancers. Data on age-adjusted mortality were obtained from the national death registry (Statistics Austria).

Results

Between 1990 and 2009, 15201 patients were diagnosed with BTC (m/f=42/58%; mean age, 73 years). The median survival of all patients with BTC was 4.8 months with a 1-/5-year survival rate of 31%/10%. In iCCC, the incidence and mortality rates increased from 1990 to 2009 in both men and women while in eCCC, the incidence and mortality rates decreased over time in both sexes. In ampullary carcinoma, the incidence slightly decreased in men and remained stable in women. The mortality rate remained stable in both sexes. In GBC, the age-adjusted incidence and mortality rates dramatically decreased in both sexes.

Conclusions

GBC and iCCC were the most common entities amongst BTC. While incidence and mortality rates of iCCC increased in men and women over time, incidence and mortality rates of eCCC and GBC decreased in both sexes. Other carcinomas of the biliary tract i.e. ampullary carcinoma were rarely diagnosed.

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