Metabolic and Steatohepatitis
Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype
Version of Record online: 25 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 34, Issue 7, pages 1084–1093, August 2014
How to Cite
Liver Int. 2014: 34: 1084–1093
- Issue online: 17 JUL 2014
- Version of Record online: 25 OCT 2013
- Accepted manuscript online: 20 SEP 2013 10:19AM EST
- Manuscript Accepted: 6 SEP 2013
- Manuscript Received: 8 MAY 2013
- NHMRC. Grant Numbers: 585411, 102818
- Australian Post-doctoral Training Fellowship. Grant Numbers: 525473, 585539
Table S1. List of primers sequences.
Fig. S1. Body weight, tissue weights, steatosis and metabolic determinants of obesity in female foz/foz and WT C57BL6/J and BALB/c mice.
Fig. S2. In female mice steatohepatitis occurs in both strains of HF-fed foz/foz mice, whereas liver fibrosis occurs in HF-fed foz/foz C57BL6/J, but not in BALB/c mice.
Fig. S3. Method for back-crossing Alms1 (foz) mutation from founder NOD.B10 strain onto BALB/c background (method for C57BL6/J was identical).
Fig. S4. Intraperitoneal glucose tolerance testing (IPGTT) of wildtype (WT) C57BL/6 mice fed 26–30 weeks either chow or the same high-fat diet (HF), as used in this study.
Fig. S5. Intraperitoneal glucose tolerance testing of foz/foz and WT BALB/c mice fed the same high-fat diet (HF), as used in this study for 8 weeks (the mice are 11 weeks of age).
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