The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma

Authors

  • Juan Bayo,

    1. Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina
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  • Mariano Marrodán,

    1. Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina
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  • Jorge B. Aquino,

    1. Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina
    2. CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
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  • Marcelo Silva,

    1. Liver Unit, Hospital Universitario Austral, Universidad Austral, Derqui-Pilar, Argentina
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  • Mariana G. García,

    1. Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina
    2. CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
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    • These two authors share credits for senior authorship.
  • Guillermo Mazzolini

    Corresponding author
    1. Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina
    2. CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
    3. Liver Unit, Hospital Universitario Austral, Universidad Austral, Derqui-Pilar, Argentina
    • Correspondence

      Guillermo Mazzolini

      Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Av. Pte. Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina

      Tel: +54 230 4482 618

      Fax: +54 230 4482 204

      e-mail: gmazzoli@cas.austral.edu.ar

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    • These two authors share credits for senior authorship.

Abstract

Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.

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