Prospective evaluation of metabolic syndrome and its components among long-term liver recipients

Authors

  • Lucilene R. Anastácio,

    1. Adult Health Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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  • Kiara G. Diniz,

    1. Adult Health Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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  • Hélem S. Ribeiro,

    1. Surgery Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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  • Lívia G. Ferreira,

    1. Surgery Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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  • Agnaldo S. Lima,

    1. Alfa Institute of Gastroenterology, Hospital of Clinics, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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  • Maria Isabel T. D. Correia,

    Corresponding author
    1. Surgery Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    2. Alfa Institute of Gastroenterology, Hospital of Clinics, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    • Correspondence

      Maria Isabel T. D. Correia, MD, PhD, Surgery Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Alfredo Balena Avenue, No. 110, Faculdade de Medicina, 5th floor, 30130-100 Belo Horizonte, Minas Gerais, Brazil

      Tel: + 55 31 91688293

      Fax: + 31 3409 9641

      e-mail: isabel_correia@uol.com.br

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  • Eduardo G. Vilela

    1. Adult Health Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    2. Alfa Institute of Gastroenterology, Hospital of Clinics, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Abstract

Background & Aims

Survival after liver transplantation (LTx) has increased. Metabolic syndrome (MS) is widely reported in patients in the early years after LTx; few studies have researched this condition in relatively long-term liver recipients. To describe, prospectively, the prevalence of MS, its components and its associated factors in relatively long-term liver recipients.

Methods

A total of 117 patients were evaluated in 2008 (median of 3 years after LTx, range 0–13 years) and in 2012 (median of 7 years after LTx, range 3–17 years) for the presence of MS [using modified NCEP Adult Treatment Panel III and International Diabetes Federation (IDF) criteria]; its components; and its associated factors, including demographic, socioeconomic, lifestyle, clinical, body composition (measured using bioelectric impedance) and dietetic factors.

Results

MS increased over the years (IDF, 43.1–53.3%, P = 0.12; and NCEP, 34.3–44.8%, P = 0.03). Blood glucose increased over the years (98.8 ± 24.7 to 109.2 ± 33.3 mg/dl, P < 0.01), which resulted in an increased prevalence of glucose intolerance (34.2–48.6%, P < 0.01). Waist circumference (93.3 ± 14.3 to 99.4 ± 14.9 cm, P < 0.01) and body fat (30.3 ± 8.9 to 31.8 ± 10.3%, P = 0.03) also increased. The MS associated factors (P < 0.05) were age [Odds ratio (OR) 1.05, confidence interval (CI) 1.02–1.11], family history of diabetes (OR 3.38, CI 1.19–9.61), body mass index (BMI) prior to liver disease (OR 1.39, CI 1.19–1.63) and body fat (OR 1.09, CI 1.03–1.14). The MS components were associated (P < 0.05) with greater age, family history of diabetes, current and previous BMI, body fat, current corticosteroid use, lack of exercise and greater carbohydrate and fat intakes.

Conclusion

MS prevalence increased over the years after LTx because of the increases in waist circumference and blood glucose. MS and its components are associated with modifiable factors, such as greater BMI, body fat and carbohydrate and fat intake.

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