Both authors contributed equally to this work.
CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV-infected Chinese population
Article first published online: 19 MAR 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 35, Issue 3, pages 786–794, March 2015
How to Cite
Liver Int. 2015; 35: 786–794
- Issue published online: 11 FEB 2015
- Article first published online: 19 MAR 2014
- Accepted manuscript online: 23 FEB 2014 04:28AM EST
- Manuscript Accepted: 13 FEB 2014
- Manuscript Received: 13 NOV 2013
- National Science and Technology Major Project. Grant Number: 2012ZX10002007
- National Natural Science Foundation of China. Grant Numbers: 81072347, 81202377
- CD24 ;
- chronic viral hepatitis;
- hepatitis C;
- viral clearance
Background & Aims
Host immune response to hepatitis C virus (HCV) is a vital factor involved in both viral clearance and liver disease pathogenesis. CD24 plays an important role in inflammation and immune response and CD24 polymorphisms are associated with risk and progression of chronic hepatitis B virus infection. Our study evaluated whether CD24 polymorphisms affect HCV clearance.
We genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions −P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing. In CHC patients, 362 individuals were treated with a recombinant IFN-α2b/ribavirin combination for 48 weeks and were followed up for an additional 24 weeks. Lymphocyte CD24 expression was analysed by flow cytometry.
We show that P170 CT and CT/TT genotypes were over-represented in the SHC group compared to CHC patients (62.8% vs. 47.2% and 75.6% vs. 60.3%, for respective polymorphisms). In multivariate logistic analysis, P170 (CD24 Ala57Val) polymorphism was an independent predictor of SHC (adjusted OR = 2.11, 95%CI = 1.19–3.73, P = 0.010 for CT genotype; OR = 2.01, 95%CI = 1.15–3.49, P = 0.014 for CT/TT genotype). No significant associations were found between the CD24 polymorphisms and treatment-induced viral clearance in log-rank analysis and Cox regression analysis. Patients with the CT/TT genotype had greater T-cell CD24 expression than patients with the CC genotype.
Our findings suggest that CD24 Ala57Val polymorphism and associated variations in CD24 expression may be an important predictor for SHC, but have no effect on antiviral drug treatment response in Chinese CHC patients.