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liv12589-sup-0001-FigureS1.tifimage/tif616KFigure S1. The purity of CD4+ T cells was confirmed as above 95% by flowcytometry.
liv12589-sup-0002-figureS2.tifimage/tif1759KFigure S2. The purity of isolated HSCs was determined by GFAP staining.
liv12589-sup-0003-figureS3.tifimage/tif690KFigure S3. By flowcytometry, above 80% of peripheral CD4+ Foxp3+ T cells in the periphery of patients with CHB were carrying the appearance of CD25high.
liv12589-sup-0004-FigureS4.tifimage/tif674KFigure S4. Under the Cell-IQ system, the representative high-power-field (400×) imaging of HSCs cocultured in contact manner with CD4+ cells from CR or PR group at TW-52 or those cultured alone are shown at Day 0 and Day 3 (HSCs are indicated with red dots while CD4+ cells are as green ones). CD4+ cells from CR or PR group barely influenced the proliferation of HSCs.
liv12589-sup-0005-FigureS5.tifimage/tif225KFigure S5. The intrahepatic mRNAs were determined using the frozen liver biopsy samples from enrolled CHB patients. Spearman's correlation analyses were performed between the intrahepatic mRNAs of the master transcriptional factors for CD4+ T subsets (such as TBX21, GATA3, Foxp3 and RORC) and the peripheral frequencies of these four CD4+ subsets (such as Th1, Th2, Treg and Th17) in CHB patients (n = 8). Data are presented as each value (r, correlation coefficient; P values are shown).

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