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liv12627-sup-0001-FigureS1.pdfapplication/PDF10KFig. S1 Analysis of miR-122 expression in various murine tissues. **P < 0.01, ***P < 0.001.
liv12627-sup-0002-FigureS2.pdfapplication/PDF16KFig. S2. (A) Representative HE-staining (left side) and TUNEL-staining (right side) of liver from CCL4-injected mice compared to oil-injected mice. (B) Serum AST levels (left panel) and serum ALT levels (right panel) are massive increased in CCL4-injected mice compared to oil-injected mice. (C) Rel. miR-122 levels in serum are significantly increased in CCL4-injected mice compared to oilinjected mice. (D) Rel. miR-122 levels in serum are strong correlated to serum AST levels in CCL4-/ oil- injected mice. (E) Rel. miR-122 levels in serum are strong correlated to serum ALT levels in CCL4-/ oil- injected mice. r = Spearman rank correlation, ***P < 0.001.
liv12627-sup-0003-FigureS3.pdfapplication/PDF13KFig. S3. (A) Rel. miR-122 levels in serum are strongly correlated to serum ALT levels in I/R-operated mice after 3, 6, 24 and 36 h reperfusion. (B) miR-122 expression in liver tissue are not correlated to serum ALT levels in I/R-operated mice after 3, 6, 24 and 36 h reperfusion. r = Spearman rank correlation.
liv12627-sup-0004-FigureS4.pdfapplication/PDF70KFig. S4. (A) Quantity of TUNEL-positive hepatocytes is strong correlated to AST levels in serum in Shamoperated mice and I/R-mice after 24 h reperfusion. (B) Quantity of TUNEL-positive hepatocytes is strong correlated to ALT levels in serum in Sham-operated mice and I/R-mice after 24 h reperfusion. r = Spearman rank correlation.
liv12627-sup-0005-FigureS5.pdfapplication/PDF11KFig. S5. (A) Rel. serum levels of miR-150 (left panel), miR-155 (middle panel) and miR-223 (right panel) are not correlated to rel. serum levels of miR-122. (B) Rel. serum levels of miR-150 (left panel), miR-155 (middle panel) and miR-223 (right panel) are not correlated to rel. serum levels of ALT. r = Spearman rank correlation.
liv12627-sup-0006-FigureS6.pdfapplication/PDF10KFig. S6. (A) Serum levels of miR-122 in critically ill patients with high Acute Physiology and Chronic Health Evaluation (APACHE) II scores (> 15) are not different in comparison to patients with low APACHE II scores (</=15). (B) Serum levels of miR-122 are not different in critically ill patients both with / without diabetes mellitus type II (left panel) and body mass index lower / higher 30 (right panel).
liv12627-sup-0007-FigureS7.pdfapplication/PDF16KFig. S7. Serum levels of miR-122 in critically ill patients with GLDH levels > 100 are significantly increased compared to GLDH levels <=100. ***P < 0.001.
liv12627-sup-0008-FigureS8.pdfapplication/PDF22K Fig. S8. (A) Serum levels of miR-122 in critically ill patients at admission to the medical ICU and after 3 days of ICU treatment, compared to healthy controls. (B) miR-122 serum levels are elevated in patients with liver injury and correlated with AST levels at day 3 of ICU treatment. ***P < 0.001.
liv12627-sup-0009-tableS1-S2.docWord document39K

Table S1. Baseline characteristics of the patients with liver fibrosis.

Table S2. Correlations of miR-122 serum concentrations of the patients with liver fibrosis with other laboratory markers.

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