T Csak and S Bala contributed equally to this study.
NAFLD & NASH
microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis
Article first published online: 27 JUL 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 35, Issue 2, pages 532–541, February 2015
How to Cite
Liver Int. 2015; 35: 532–541
- Issue published online: 22 JAN 2015
- Article first published online: 27 JUL 2014
- Accepted manuscript online: 10 JUL 2014 09:57AM EST
- Manuscript Accepted: 6 JUL 2014
- Manuscript Received: 20 NOV 2013
- NIAAA. Grant Number: AA020744
Data. S1. Supplementary Methods.
Fig. S1. MCD diet induces steatohepatitis.
Fig. S2. Putative binding sites of miR-122 at the 3UTR region of MAP3K3 and HIF-1α and overexpression on miR-122 in primary murine hepatocytes.
Fig. S3. Increase in apoptotic (caspase-8) and anti-apoptotic (bcl2) protein/gene expression in MCD-livers.
Fig. S4. miR-122 expression in hepatic stellate cells.
Fig. S5. Correlation between serum ALT and serum miR-122.
Fig. S6. Proposed model for miR-122 role in NASH.
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