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Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis

Authors

  • Mariela Nissensohn,

    Corresponding author
    1. Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Madrid, Spain
    • Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
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  • Almudena Sánchez Villegas,

    1. Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
    2. Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Madrid, Spain
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  • Daniel Fuentes Lugo,

    1. Faculty of Health Sciences, Unacar, Ciudad del Carmen, Mexico
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  • Patricia Henríquez Sánchez,

    1. Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
    2. Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Madrid, Spain
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  • Jorge Doreste Alonso,

    1. Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
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  • Nicola M. Lowe,

    1. International Institute of Nutritional Sciences and Food Safety Studies, University of Central Lancashire, Preston, UK
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  • Victoria Hall Moran,

    1. Maternal & Infant Nutrition & Nurture Unit, University of Central Lancashire, Preston, UK
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  • Anna Louise Skinner,

    1. International Institute of Nutritional Sciences and Food Safety Studies, University of Central Lancashire, Preston, UK
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  • Marisol Warthon Medina,

    1. International Institute of Nutritional Sciences and Food Safety Studies, University of Central Lancashire, Preston, UK
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  • Lluis Serra-Majem

    1. Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
    2. Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Madrid, Spain
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Errata

This article is corrected by:

  1. Errata: Erratum Volume 11, Issue 4, 1056, Article first published online: 29 September 2015

Correspondence: Mariela Nissensohn, PhD, Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35016, Spain. E-mail: mnissensohn@acciones.ulpgc.es

Abstract

A systematic review and meta-analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta-regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054; <0.001 and <0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4–20 weeks and >20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12 mg day−1. In all cases, the pooled β showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence-based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.

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