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Section 1 Predator abundance estimation details and pcr information.

Table S1 Environmental description of localities.

Fig. S1 Map and localization of the study sites.

Section 2 Component analyses of environmental variables and spatial distribution.

Table S2 Component analysis for mixtures of quantitative and qualitative variables.

Table S3 Correlogram results from habitat parameters (CS1 and CS2).

Fig. S2 Visualization of environmental characters in CS1 and CS2.

Fig. S3 Correlograms results from habitat parameters (CS1 and CS2).

Section 3 Landscape resistance models: testing isolation by resistance.

Table S4 Conductance values for each land-cover type.

Table S5 Results and correlation coefficients of the IBR models.

Fig. S4 Map with the study area showing the cover types, landscapes and sampling sites.

Fig. S5 Resistance map for the best IBR model.

Fig. S6 Mean ± 2 SE of (a) mass at metamorphosis, (b) larval period, and (c) growth rate.

Section 4 Description of TRβ Haplotypes and genotypic information per population.

Table S6 Base composition of TRβ haplotypes detected and their frequencies.

Table S7 Summary statistics for TRβ gene variation in the 17 R. Arvalis populations.

Table S8 FSTS for TRβ between population pairs.

Table S9 Results from the machine-learning approach for phenotype-TRβ gene relationship.

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