Balancing selection and heterozygote advantage in major histocompatibility complex loci of the bottlenecked Finnish wolf population
Version of Record online: 29 JAN 2014
© 2013 John Wiley & Sons Ltd
Volume 23, Issue 4, pages 875–889, February 2014
How to Cite
Niskanen, A. K., Kennedy, L. J., Ruokonen, M., Kojola, I., Lohi, H., Isomursu, M., Jansson, E., Pyhäjärvi, T. and Aspi, J. (2014), Balancing selection and heterozygote advantage in major histocompatibility complex loci of the bottlenecked Finnish wolf population. Molecular Ecology, 23: 875–889. doi: 10.1111/mec.12647
- Issue online: 29 JAN 2014
- Version of Record online: 29 JAN 2014
- Accepted manuscript online: 30 DEC 2013 10:50AM EST
- Manuscript Accepted: 20 DEC 2013
- Manuscript Revised: 19 DEC 2013
- Manuscript Received: 25 JUN 2013
- Finnish Population Genetics Graduate School
- Kone foundation
- Academy of Finland. Grant Numbers: 127065, 116579
- Jane and Aatos Erkko Foundation
- Jenny and Antti Wihuri Foundation
Table S1 Microsatellite diversity of Finnish and Karelian wolf populations.
Table S2 Sample information, MHC and microsatellite genotypes for Finnish and Russian Karelian wolf samples used in this study.
Fig. S1 Linkage disequilibrium measured as r2 between SNPs in wolf MHC loci DLA-DRB1, DLA-DQA1 and DLA-DQB1.
Fig. S2 Codons under balancing selection according to OmegaMap analysis in Russian Karelian wolves, the number of synonymous polymorphisms (dS) subtracted from the number of nonsynonymous polymorphisms (dN) and codons putatively belonging to the peptide-binding regions suggested by Brown et al. (1988, 1993) for (a) DLA-DRB1, (b) DLA-DQA1 and (c) DLA-DQB1.
Appendix S1 Supporting material and methods and results, including Table S1 and Fig. S1.
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