Neutrophil-Mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps

Authors

  • Jamie E. Meegan,

    1. Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
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  • Xiaoyuan Yang,

    1. Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
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  • Danielle C. Coleman,

    1. Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
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  • Melanie Jannaway,

    1. Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
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  • Sarah Y. Yuan

    Corresponding author
    1. Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
    • Correspondence:

      Sarah Yuan, MD, PhD

      Professor and Chair

      Department of Molecular Pharmacology and Physiology

      University of South Florida Morsani College of Medicine

      12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612

      813-974-5104

      813-974-3079 (Fax)

      syuan@health.usf.edu

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  • This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/micc.12352

Abstract

Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium crosstalk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.

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