Is fungal foot infection the initiating and maintaining cause of knee osteoarthritis?
Article first published online: 8 APR 2013
© 2013 Blackwell Verlag GmbH
Volume 56, Issue 6, pages 631–637, November 2013
How to Cite
Řenč, A. (2013), Is fungal foot infection the initiating and maintaining cause of knee osteoarthritis?. Mycoses, 56: 631–637. doi: 10.1111/myc.12080
- Issue published online: 22 OCT 2013
- Article first published online: 8 APR 2013
- Manuscript Accepted: 15 MAR 2013
- Manuscript Revised: 25 NOV 2012
- Manuscript Received: 8 OCT 2012
So far fungal foot infection (FFI) has been considered as troubling, however, not dangerous, by the general public as well as doctors. Nevertheless, new immunology information and anatomy dispositions led us to the distinct suspicions. We propose a FFI–induced knee joint osteoarthritis (OA) model. We suppose repeated recurrences of fungal foot disease to be the initiating immunology impulse. The aim of the work is to introduce a new model and to determine antigen epitopes initiating and maintaining the knee OA using computer simulation. Freely accessible immunological databases and servers were used in this search. Presentable antigen epitopes in Trichophyton rubrum dermatophyte products were identified for molecules of the six most abundant alleles of DRB1 locus of human major histocompatibility complex. Subsequently, similar sequences in human joint peptides (collagens, aggrecan and others) were matched to these antigen epitopes by a comparative program. A number of pairs with very similar fungal and joint peptide sequences, supposed to initiate and maintain the knee OA antigen epitopes, were found. A FFI-induced knee joint OA model is shown to the medical community which can initiate further discussion, research and practical verification.